Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antihypertensive Drugs: Potassium-Sparing Diuretics01:28

Antihypertensive Drugs: Potassium-Sparing Diuretics

569
Liddle syndrome is a genetically inherited form of hypertension characterized by the overactivity of epithelial sodium channels in the nephron, the functional unit of the kidney. This heightened activity leads to increased sodium reabsorption and excessive excretion of potassium. To counteract this, potassium-sparing diuretics such as amiloride are used. They function by blocking these sodium channels, thereby reducing the influx of sodium into the epithelial cells and minimizing the loss of...
569
Antiarrhythmic Drugs: Class III Agents as Potassium Channel Blockers01:12

Antiarrhythmic Drugs: Class III Agents as Potassium Channel Blockers

1.0K
Class III antiarrhythmic drugs are a group of medications that can prolong action potentials in the heart. They achieve this by blocking potassium channels or enhancing inward currents from sodium channels. However, these drugs have a unique property of "reverse use-dependence," which is most pronounced at slower heart rates and can lead to torsades de pointes—a specific type of arrhythmia. However, it is essential to note that excessive QT interval prolongation—a measure of...
1.0K
Regulation of Sodium and Potassium01:26

Regulation of Sodium and Potassium

541
The regulation of sodium and potassium ion concentrations in the human body is a complex process governed primarily by hormones such as aldosterone, antidiuretic hormone (ADH), and atrial natriuretic peptide (ANP).
Sodium Regulation
Sodium ions make up approximately 90% of extracellular cations, with a normal blood plasma concentration of 136–148 mEq/L. A decrease in blood volume and pressure triggers the release of renin from granular cells in the juxtaglomerular complex (JGC), primarily...
541
Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

388
Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
388
Heart Failure Drugs: Inotropic Agents01:26

Heart Failure Drugs: Inotropic Agents

591
Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
591
Antiarrhythmic Drugs: Class I Agents as Sodium Channel Blockers01:22

Antiarrhythmic Drugs: Class I Agents as Sodium Channel Blockers

1.4K
Class I antiarrhythmic drugs are used to treat various types of arrhythmias or irregular heart rhythms. These drugs block the sodium (Na+) channels in the cardiac cells, thereby affecting the movement of electrical impulses across the heart. Class I antiarrhythmic drugs are divided into three subgroups: Class IA, Class IB, and Class IC, each with distinct mechanisms of action and effects on the heart.
Class 1A Antiarrhythmic Drugs: These drugs work by moderately blocking sodium channels,...
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

UWB-Based Self-Localization Strategies: A Novel ICP-Based Method and a Comparative Assessment for Noisy-Ranges-Prone Environments.

Sensors (Basel, Switzerland)·2020
Same author

Views of Farmers and Industrial Entrepreneurs on The Iberian Pig Quality Standard: An In-Depth Interview Research Study.

Animals : an open access journal from MDPI·2020
Same author

IL-17A as a Potential Therapeutic Target for Patients on Peritoneal Dialysis.

Biomolecules·2020
Same author

Effect of Coffee Consumption on Renal Outcome: A Systematic Review and Meta-Analysis of Clinical Studies.

Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation·2020
Same author

The effect of energy restriction on development and progression of chronic kidney disease: review of the current evidence.

The British journal of nutrition·2020
Same author

Sweet dreams: therapeutic insights, targeting imaging and physiologic evidence linking sleep, melatonin and diabetic nephropathy.

Clinical kidney journal·2020

Related Experiment Video

Updated: Jul 6, 2025

Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

18.8K

Consensus document on the management of hyperkalemia.

Alberto Ortiz1, Carmen Del Arco Galán2, José Carlos Fernández-García3

  • 1Sociedad Española de Nefrología (S.E.N.), Spain.

Nefrologia
|January 3, 2024
PubMed
Summary

Hyperkalaemia, a common electrolyte imbalance, poses significant health risks. This consensus document provides a unified, updated approach to managing hyperkalaemia, incorporating new drug treatments.

Keywords:
Chronic kidney diseaseCiclosilicato de sodio y zirconioDiabetes mellitusEnfermedad renal crónicaHeart failureHiperpotasemiaHyperkalaemiaInsuficiencia cardiacaPatiromerSodium zirconium cyclosilicateTratamientoTreatment

More Related Videos

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

12.1K
Voltage-Dependent Potassium Current Recording on H9c2 Cardiomyocytes via the Whole-Cell Patch-Clamp Technique
08:11

Voltage-Dependent Potassium Current Recording on H9c2 Cardiomyocytes via the Whole-Cell Patch-Clamp Technique

Published on: November 11, 2022

2.8K

Related Experiment Videos

Last Updated: Jul 6, 2025

Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

18.8K
Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

12.1K
Voltage-Dependent Potassium Current Recording on H9c2 Cardiomyocytes via the Whole-Cell Patch-Clamp Technique
08:11

Voltage-Dependent Potassium Current Recording on H9c2 Cardiomyocytes via the Whole-Cell Patch-Clamp Technique

Published on: November 11, 2022

2.8K

Area of Science:

  • Internal Medicine
  • Cardiology
  • Endocrinology
  • Nephrology
  • Emergency Medicine

Background:

  • Hyperkalaemia is a prevalent electrolyte disorder with serious health implications.
  • Management is fragmented across specialties, necessitating a unified approach.
  • New drug therapies require updated clinical guidelines.

Purpose of the Study:

  • To review fundamental aspects of potassium balance and hyperkalaemia.
  • To outline the concept, epidemiology, pathophysiology, and diagnostic strategies.
  • To provide updated therapeutic recommendations for hyperkalaemia management.

Main Methods:

  • Consensus document developed by leading Spanish scientific societies.
  • Comprehensive review of existing evidence and published studies.
  • Focus on a multidisciplinary approach to patient care.

Main Results:

  • Provides a foundational understanding of potassium homeostasis.
  • Details the clinical presentation and underlying mechanisms of hyperkalaemia.
  • Offers guidance on current diagnostic and therapeutic interventions.

Conclusions:

  • Emphasizes the need for a standardized, multidisciplinary approach to hyperkalaemia.
  • Highlights the importance of updated management strategies.
  • Aims to serve as a practical tool for clinicians managing hyperkalaemia.