Related Experiment Video

Updated: Jul 6, 2025

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

14.9K

Temporal trends in antipsychotic prescriptions for pediatric patients using an administrative hospital database in

Daisuke Kikuchi1, Taku Obara2,3,4, Ryo Obara5

  • 1Department of Pharmacy, Tohoku Medical and Pharmaceutical University Hospital, 1-12-1 Fukumuro, Miyagino-ku, Sendai, 983-8512, Miyagi, Japan.

Journal of Pharmaceutical Health Care and Sciences
|January 3, 2024
PubMed

Insights

Antipsychotic prescribing trends for pediatric schizophrenia in Japan show a significant increase in aripiprazole use from 2015 to 2022. Risperidone prescriptions decreased during the same period for both male and female patients.

Area of Science:

  • Psychiatry
  • Pediatric Medicine
  • Pharmacology

Background:

  • Schizophrenia is a severe mental disorder affecting children and adolescents.
  • Current Japanese treatment guidelines do not recommend specific drugs for pediatric schizophrenia.
  • Temporal prescription trends for antipsychotics in pediatric schizophrenia are not well-documented.

Purpose of the Study:

  • To analyze antipsychotic prescription trends in Japanese pediatric outpatients diagnosed with schizophrenia.
  • To investigate changes in drug selection between 2015 and 2022.

Main Methods:

  • Utilized administrative data from Japanese acute-care hospitals (2015-2022).
  • Included pediatric outpatients aged 0-18 years with schizophrenia.
  • Calculated annual prescription proportions for antipsychotics and used the Cochran-Armitage trend test for statistical analysis.

Main Results:

  • Aripiprazole and risperidone were the most frequently prescribed antipsychotics.
  • Prescription proportions for aripiprazole significantly increased in both male (21.2% to 35.9%) and female (21.6% to 35.6%) patients from 2015 to 2022.
  • Prescription proportions for risperidone significantly decreased in both male (47.9% to 36.7%) and female (38.6% to 24.8%) patients during the same period.

Conclusions:

  • Aripiprazole and risperidone were the primary antipsychotics used for pediatric schizophrenia in Japan.
  • A significant upward trend in aripiprazole prescriptions was observed over the study period.
Abstract

Keywords:
AripiprazolePediatricsPrescriptionPrevalenceSchizophrenia

More Related Videos

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization09:57

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Published on: September 20, 2024

2.7K
Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD10:02

Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD

Published on: March 12, 2020

15.7K

Related Concept Videos

Drug Therapy01:28

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
45
Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
135
Prescription, Nonprescription and Orphan Drugs01:02

Prescription, Nonprescription and Orphan Drugs

Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
736
Factors Affecting Drug Response: Overview01:21

Factors Affecting Drug Response: Overview

When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
2.0K
Psychosis and Antipsychotic Drugs: Overview01:28

Psychosis and Antipsychotic Drugs: Overview

The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
271
Analysis of Population Pharmacokinetic Data01:12

Analysis of Population Pharmacokinetic Data

Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
264