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Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality
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Human organoids-on-chips for biomedical research and applications
Hui Wang1,2, Xiufan Ning1, Feng Zhao3
1Department of Interventional & Vascular Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong 226001, China.
Theranostics
|January 3, 2024
Summary
Human organoids-on-chips (OrgOCs) combine organoids and microfluidics to create advanced 3D living models. These models better predict human responses, improving preclinical research and precision medicine.
Area of Science:
- Biomedical Engineering
- Tissue Engineering
- Organoid Technology
Background:
- Human organoids-on-chips (OrgOCs) integrate human organoids (HOs) with microfluidic organs-on-chips (OOCs).
- OOCs replicate tissue microenvironments, while HOs allow biological analysis and genetic manipulation.
- OrgOCs offer 3D organotypic living models that recapitulate tissue-specific properties.
Purpose of the Study:
- To review cutting-edge achievements in OrgOCs.
- To introduce key features of OrgOCs architectures.
- To discuss applications in basic biology, disease modeling, preclinical assays, and precision medicine.
Main Methods:
- Review of recent literature on OrgOCs.
- Analysis of OrgOCs architectures and their functionalities.
- Exploration of interdisciplinary approaches for OrgOCs development.
Main Results:
- OrgOCs represent a significant advancement over 2D cell cultures and animal models for human ecological niche modeling.
- These models show promise for clinical studies and preclinical-to-clinical translation.
- OrgOCs have diverse applications in various biomedical fields.
Conclusions:
- OrgOCs are revolutionary living models with vast potential in biomedical research.
- Combining diverse disciplines with OrgOCs can accelerate translational applications.
- Addressing challenges and opportunities will drive future OrgOCs development.
