Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Trimester-specific reference intervals for coagulation biomarkers (TAT, PIC, TM, tPAI-C) and their clinical associations in healthy Chinese pregnant women.

Scientific reports·2026

Same author

Red electroluminescent Cu<sub>4</sub>I<sub>4</sub> bipyramids with external quantum efficiency beyond 40.

Nature communications·2026

Same author

Biosensors with enzymatic amplification strategies for the detection of foodborne pathogenic microorganisms.

Biotechnology advances·2026

Same author

The Effects of Different Organic Amendment Strategies on Soil Properties and Microbial Communities in Maize Monocropping.

Plants (Basel, Switzerland)·2026

Same author

Characterization and Molecular Modification of a Cold-Adapted β-Galactosidase from <i>Flavobacterium algicola</i> for Preparation of Lactose-Free Milk.

Journal of agricultural and food chemistry·2026

Same author

Tunable electrosynthesis of functionalized phenoxazines from alcohols and P<sub>4</sub>S<sub>10</sub>.

Organic & biomolecular chemistry·2026

Search research articles

Related Experiment Video

Updated: Jul 6, 2025

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Published on: January 26, 2016

MYC-Targeting Inhibitors Generated from a Stereodiversified Bicyclic Peptide Library.

Zhonghan Li¹, Yi Huang¹, Ta I Hung¹

¹Department of Chemistry, University of California, Riverside, Riverside, California 92521, United States.

Journal of the American Chemical Society

|January 3, 2024

Summary

This summary is machine-generated.

We developed a new bicyclic peptide library (NTB) using a novel ring-opening/closing metathesis reaction. This library successfully identified MYC-targeting peptides, with NT-B2R inhibiting MYC transcription and cell growth.

More Related Videos

Semi-automated Biopanning of Bacterial Display Libraries for Peptide Affinity Reagent Discovery and Analysis of Resulting Isolates

Semi-automated Biopanning of Bacterial Display Libraries for Peptide Affinity Reagent Discovery and Analysis of Resulting Isolates

Published on: December 6, 2017

Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library

Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library

Published on: September 30, 2019

Related Experiment Videos

Last Updated: Jul 6, 2025

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Published on: January 26, 2016

Semi-automated Biopanning of Bacterial Display Libraries for Peptide Affinity Reagent Discovery and Analysis of Resulting Isolates

Semi-automated Biopanning of Bacterial Display Libraries for Peptide Affinity Reagent Discovery and Analysis of Resulting Isolates

Published on: December 6, 2017

Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library

Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library

Published on: September 30, 2019

Area of Science:

Medicinal Chemistry
Organic Chemistry
Molecular Biology

Background:

Macrocyclic peptides offer therapeutic potential but face challenges in synthesis and screening.
Developing efficient methods for constructing and analyzing peptide libraries is crucial for drug discovery.
Targeting oncoproteins like MYC is a key strategy in cancer therapy.

Purpose of the Study:

To introduce the second generation of the bicyclic peptide library (NTB) with improved design and synthesis.
To apply the NTB library for the identification of novel MYC-targeting agents.
To evaluate the therapeutic potential of identified MYC-targeting bicyclic peptides.

Main Methods:

Utilized a tandem ring-opening metathesis and ring-closing metathesis (ROM-RCM) reaction for one-step cyclization of linear peptides.
Developed a facile one-step deallylation process for MS/MS sequencing of bicyclic peptides.
Screened the NTB library against the E363-R378 epitope of MYC and performed in vitro cell studies.

Main Results:

Successfully synthesized a stereodiversified bicyclic peptide library using an efficient ROM-RCM strategy.
Identified several bicyclic peptides that target MYC.
Demonstrated that the candidate NT-B2R effectively suppressed MYC transcription and cell proliferation in vitro.

Conclusions:

The NTB library provides a powerful and versatile platform for the discovery of macrocyclic peptide therapeutics.
The developed ROM-RCM approach represents a significant advancement in macrocyclic peptide synthesis.
NT-B2R shows promise as a potential therapeutic agent for MYC-driven cancers.