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Development of Platinum Complexes for Tumor Chemoimmunotherapy
Suxing Jin1,2, Yan Guo3, Xiaoyong Wang2
1School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing, 210023, P. R. China.
Chemistry (Weinheim an Der Bergstrasse, Germany)
|January 3, 2024
Summary
Platinum complexes enhance cancer treatment by combining chemotherapy with immunotherapy. These platinum compounds not only kill tumor cells but also modulate the immune system, improving drug resistance and reducing toxicity.
Area of Science:
- Oncology
- Immunology
- Medicinal Chemistry
Background:
- Platinum complexes are established chemotherapy agents.
- Emerging evidence highlights their immunomodulatory roles in antitumor activity.
- Combining chemotherapy with immunotherapy offers enhanced therapeutic potential.
Purpose of the Study:
- To review the concept of chemoimmunotherapy.
- To summarize recent advancements of platinum complexes as chemoimmunotherapeutic agents.
- To explore the multifaceted roles of platinum complexes in cancer treatment.
Main Methods:
- Literature review of chemoimmunotherapy and platinum complexes.
- Analysis of platinum complexes' mechanisms in inducing immunogenic cell death.
- Examination of platinum complexes' roles in immune checkpoint blockade and immune signaling modulation.
Main Results:
- Platinum complexes exhibit both cytotoxic and immunomodulatory effects.
- They can be developed as inducers of immunogenic cell death.
- Platinum complexes act as immune checkpoint blockers and regulators of the tumor immune microenvironment.
Conclusions:
- Synergistic chemoimmunotherapy with platinum complexes enhances antitumor activity.
- This approach helps overcome drug resistance and systemic toxicity.
- Platinum complexes offer new avenues for developing metal-based anticancer drugs.
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