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Development of Fast Disintegrating Tablets Containing Loxoprofen Sodium by HYDROFLASH Manufacturing Method
Aya Kuwata1,2, Tetsuo Ono2, Yuri Tsuchiya2
1Department of Physical Chemistry, Hoshi University.
Chemical & Pharmaceutical Bulletin
|January 3, 2024
Summary
A new HYDROFLASH manufacturing method enables fast disintegration of loxoprofen sodium (LX) tablets. This pharmaceutical innovation significantly reduces disintegration time for rapid headache and fever relief.
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
Background:
- Loxoprofen sodium (LX) tablets are difficult to disintegrate, delaying relief from headache and fever.
- High viscosity of LX in water inhibits tablet disintegration by slowing water penetration.
Purpose of the Study:
- To develop a superior manufacturing method for fast-disintegrating LX tablets.
- To improve the dissolution rate and efficacy of LX pharmaceuticals.
Main Methods:
- Screening of excipients to identify optimal disintegrants.
- Development of the HYDROFLASH manufacturing method using fluidized-bed granulation.
- Incorporation of light anhydrous silicic acid (LASA) dispersion during granulation.
Main Results:
- Mannitol tablets showed a 2-minute disintegration time.
- The HYDROFLASH method achieved disintegration in approximately 30 seconds.
- LASA was uniformly distributed on tablet surfaces, facilitating rapid water penetration.
- LX dissolution rate reached nearly 100% within 5 minutes.
Conclusions:
- The HYDROFLASH method effectively overcomes LX viscosity issues for rapid tablet disintegration.
- This method enhances LX bioavailability and accelerates therapeutic effects.
- Uniform LASA distribution is key to the improved performance of LX tablets.
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