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Uncovering dark matter in cancer by identifying epigenetic drivers

Jun Zhong1, Laufey T Amundadottir1

  • 1Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Trends in Genetics : TIG
|January 3, 2024
PubMed

Keywords:
cancer transitiondifferentially accessible chromatin region (DACR)drug targetenhancer activityepigenetic driversnATAC-seq

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Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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