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Updated: Jul 6, 2025

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Synthesis of alnustone-like diarylpentanoids via a 4 + 1 strategy and assessment of their potential anticancer
Neslihan Çelebioğlu1, Özlem Özdemir Tozlu2, Hasan Türkez3
1Department of Chemistry, Faculty of Sciences, Atatürk University, Erzurum, Turkiye.
Abstract:
Twelve compounds with a 1,5-diaryl-1-penten-3-one structure were synthesized and their cytotoxic activities were evaluated. The 1,5-diaryl-1-penten-3-one compounds were obtained via in situ enaminations of 4-phenyl-2-butanone and 4-(4-hydroxyphenyl)-2-butanone in the presence of pyrrolidine-AcOH, followed by condensation with six different benzaldehydes. The synthesized compounds were tested for their cytotoxic activity against human glioblastoma (U87-MG), breast (MCF-7), and prostate (PC-3) cancer cell lines. Some of the novel compounds exhibited remarkable cytotoxic action, especially against MCF-7 cancer cells.
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