[Modeling of induction and elimination of sister chromatid exchanges in time]

Induction and elimination of sister chromatid exchanges (SCE) have been simulated during several cell cycles. Two models of SCE elimination are suggested. The first model postulates that the mutagen-induced lesions are not repaired, a lesion being only inherited by one daughter cell after DNA synthesis. According to the second model, lesions are completely repaired at the first S-phase. No SCE induction takes place during next cell cycles. SCE frequency ranges for both models are described by an equation, including the probability distribution function. The best correspondence in experimental and theoretical results was obtained using the model claiming repair of lesions during one cell cycle.