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Gastroesophageal Reflux and Chronic Rhinosinusitis: A Mendelian Randomization Study
1Clinical Medical College, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
The Laryngoscope
|January 4, 2024
Summary
Gastroesophageal reflux (GERD) independently increases chronic rhinosinusitis (CRS) risk. Asthma mediates this link, suggesting GERD contributes to unified airway disease.
Area of Science:
- Genetics and Epidemiology
- Otolaryngology
- Gastroenterology
Background:
- Chronic rhinosinusitis (CRS) is frequently observed in patients with gastroesophageal reflux (GERD), but a causal link remains debated.
- Understanding the etiological relationship between GERD and CRS is crucial for managing upper airway diseases.
Purpose of the Study:
- To investigate the potential causal relationship between GERD and CRS using a two-sample Mendelian Randomization (MR) analysis.
- To explore the mediating role of asthma in the association between GERD and CRS.
Main Methods:
- Genome-wide association studies (GWAS) data were utilized to identify genetic variants for GERD and CRS.
- Univariable and multivariable MR analyses, including inverse variance weighted (IVW) methods, were performed to assess causality and adjust for confounders.
- Network MR analysis was employed to quantify the mediating effect of asthma.
Main Results:
- GERD was significantly associated with an increased risk of CRS (IVW OR = 1.30).
- Treatment for GERD (Omeprazole) showed a reduced risk of CRS (IVW OR = 0.64).
- Asthma was found to mediate 19.65% of the causal effect between GERD and CRS, independent of other factors like smoking and BMI.
Conclusions:
- GERD is an independent risk factor for developing CRS.
- The findings highlight GERD as a contributing factor to unified airway disease through mechanisms involving asthma mediation.
Keywords:
asthmachronic rhinosinusitisgastroesophageal refluxmediation analysismultivariable Mendelian randomizationMore Related Videos
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