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Home Oxygen After Hospitalization for COVID-19: Results From the Multi-Center OXFORD Study
Michael B Freedman1, Yoo Jin Kim2, Ramandeep Kaur2
1Drs Freedman and Kaul are affiliated with Division of Pulmonary, Critical Care, Sleep, and Allergy, Department of Medicine, University of Illinois Chicago, Chicago, Illinois; and Medical Service, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois. Drs Kim, Labedz, and Taylor and Ms Ziauddin are affiliated with Division of Pulmonary, Critical Care, Sleep, and Allergy, Department of Medicine, University of Illinois Chicago, Chicago, Illinois. Drs Kaur and Vines and Mr Rintz are affiliated with Division of Respiratory Care, Department of Cardiopulmonary Sciences, Rush University, Chicago, Illinois. Dr Jain is affiliated with Medical Service, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois; and Division of Hospital Medicine, Department of Medicine, Northwestern University, Chicago, Illinois. Dr Adegunsoye is affiliated with Section of Pulmonary Critical and Critical Care, Department of Medicine, University of Chicago, Chicago, Illinois. Dr Chung and Ms DeLisa are affiliated with Office of Population Health Sciences, University of Illinois Hospital and Health Sciences System, Chicago, Illinois. Ms Gardner is affiliated with Research Service, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois. Drs Gordon and Khouzam are affiliated with Medical Service, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois; and Academic Internal Medicine and Geriatrics, Department of Medicine, University of Illinois Chicago, Chicago, Illinois. Drs Greenberg and Mokhlesi are affiliated with Division Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Rush University, Chicago, Illinois. Dr Rubinstein is affiliated with Division of Pulmonary, Critical Care, Sleep, and Allergy, Department of Medicine, University of Illinois Chicago, Chicago, Illinois; Medical Service, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois; and Research Service, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois. Drs Gerald and Krishnan are affiliated with Division of Pulmonary, Critical Care, Sleep, and Allergy, Department of Medicine, University of Illinois Chicago, Chicago, Illinois; and Office of Population Health Sciences, University of Illinois Hospital and Health Sciences System, Chicago, Illinois. mfreed2@uic.edu.
About a quarter of hospitalized COVID-19 patients required home oxygen, even after effective treatments were available. Further research is needed for strategies to reduce this home oxygen requirement.
Area of Science:
- Pulmonary Medicine
- Infectious Diseases
- Critical Care
Background:
- Home oxygen use was common in early COVID-19 pandemic hospitalizations before effective treatments.
- Little is known about home oxygen needs post-hospitalization after proven treatments were established.
Purpose of the Study:
- To investigate the prevalence and predictors of home oxygen use in patients hospitalized with COVID-19 after evidence-based treatments were available.
Main Methods:
- Retrospective, multi-center cohort study of 517 patients hospitalized for COVID-19 between October 2020 and September 2021.
- Data abstracted from electronic health records, including demographics, comorbidities, treatments, and 60-day post-discharge outcomes.
- Used World Health Organization COVID-19 Clinical Progression Scale to define severe disease.
Main Results:
- 26% of patients were discharged on home oxygen.
- Predictors for home oxygen included older age, higher BMI, diabetes, severe COVID-19, and systemic corticosteroid use.
- Hypertension was associated with decreased home oxygen need.
- Within 60 days post-discharge, 46% of patients with documented pulse oximetry had home oxygen discontinued.
Conclusions:
- Home oxygen prescription remains common for COVID-19 survivors post-hospitalization, despite established effective treatments.
- Evidence-based strategies are needed to minimize home oxygen requirements in these patients.
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