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Short-term and medium-term clinical outcomes of multisystem inflammatory syndrome in children: a prospective
Anastasia Glazyrina1, Elena Zholobova2, Ekaterina Iakovleva3
1Morozovskaya Children's Municipal Clinical Hospital of the Moscow City Health Department, Moscow, Russia.
Background:
Even though the incidence of Multisystem Inflammatory Syndrome in children (MIS-C) is decreasing cases are still reported across the world. Studying the consequences of MIS-C enhances our understanding of the disease's prognosis. The objective of this study was to assess short- and medium-term clinical outcomes of MIS-C.
Methods:
Prospective observational cohort study at Municipal Children's Hospital Morozovskaya, Moscow, Russia. All children meeting the Royal College of Paediatrics and Child Health (RCPCH), Centers for Disease Control and Prevention (CDC), or the World Health Organization (WHO) MIS-C case definition admitted to the hospital between 17 May and 26 October 2020 were included in the study. All survivors were invited to attend a clinic at 2 and 6 weeks after hospital discharge.
Results:
37 children median age 6 years (interquartile range [IQR] 3.3-9.4), 59.5% (22/37) boys were included in the study. 48.6% (18/37) of patients required ICU care. One child died. All children had increased levels of systemic inflammatory markers during the acute event. Echocardiographic investigations identified abnormal findings in 35.1% (13/37) of children. 5.6% (2/36) of children were presenting with any symptoms six weeks after discharge. By six weeks the inflammatory markers were within the reference norms in all children. The echocardiographic evaluation showed persistent coronary dilatation in one child.
Conclusions:
Despite the severity of their acute MIS-C, the majority of children in our cohort fully recovered with none having elevated laboratory markers of inflammation at 6 weeks, few (< 10%) reporting persistent symptoms at 6 weeks, and only one with persistent echocardiographic abnormalities.
Insights
Most children with Multisystem Inflammatory Syndrome in children (MIS-C) recover well, with few experiencing lasting symptoms or inflammation markers six weeks after discharge. This study tracked MIS-C outcomes in children.
Area of Science:
- Pediatrics
- Infectious Diseases
- Cardiology
Background:
- Multisystem Inflammatory Syndrome in children (MIS-C) incidence is decreasing but remains a global concern.
- Understanding MIS-C consequences is crucial for disease prognosis.
- This study assesses short- and medium-term clinical outcomes of MIS-C.
Purpose of the Study:
- To evaluate the clinical outcomes of children diagnosed with MIS-C.
- To assess the resolution of inflammatory markers and symptoms post-discharge.
- To identify any persistent echocardiographic abnormalities.
Main Methods:
- Prospective observational cohort study conducted in Moscow, Russia.
- Included 37 children meeting established MIS-C case definitions (RCPCH, CDC, WHO).
- Follow-up assessments at 2 and 6 weeks post-discharge included clinical evaluation and laboratory tests.
Main Results:
- 37 children (median age 6 years, 59.5% boys) were studied; 48.6% required ICU care.
- 35.1% had abnormal echocardiographic findings during the acute phase.
- By 6 weeks, only 5.6% reported symptoms, inflammatory markers normalized in all, and one child had persistent coronary dilatation.
Conclusions:
- The majority of children with MIS-C experienced full recovery.
- Few children had persistent symptoms or elevated inflammatory markers at 6 weeks.
- Persistent echocardiographic abnormalities were rare, observed in only one case.
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