Correlation between Mean Platelet Volume and Gensini Score in Patients with Coronary Heart Disease in Different Diabetic States
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Qining Qiu1, Guohong Zhu2, Gang Peng3
1Department of Pharmacy, Zhongshan Hospital (Xiamen), Fudan University, 361015 Xiamen, Fujian, China; Department of Pharmacy, Zhongshan Hospital, Fudan University, 200032 Shanghai, China. qiu.qining@zs-hospital.sh.cn.
Insights
Mean platelet volume (MPV) can predict coronary artery stenosis severity in stable coronary heart disease (CHD) patients. This association is stronger in patients with diabetes, highlighting MPV
Area of Science:
- Cardiology
- Hematology
- Diabetology
Background:
- Stable coronary heart disease (CHD) poses a significant health burden.
- Assessing coronary artery stenosis severity is crucial for patient management.
- Mean platelet volume (MPV) is an indicator of platelet activation and size.
Purpose of the Study:
- To investigate the correlation between mean platelet volume (MPV) and Gensini scores in stable coronary heart disease (CHD) patients.
- To determine if diabetes influences the relationship between MPV and coronary artery disease severity.
Main Methods:
- Retrospective analysis of 2525 stable CHD patients.
- Patients categorized into low and high MPV groups based on median levels.
- Coronary artery disease severity quantified using the Gensini score.
Main Results:
- Higher Gensini scores observed in the high MPV group (p < 0.001).
- MPV positively correlated with the number of stenotic coronary vessels (p < 0.001).
- MPV demonstrated a stronger positive correlation with Gensini score in diabetic patients (r = 0.232, p < 0.001).
- MPV showed higher predictive value for high Gensini scores in the diabetes cohort (AUC: 0.635).
- Diabetes and MPV were independently associated with Gensini scores.
Conclusions:
- Mean platelet volume (MPV) levels predict coronary artery stenosis severity in stable CHD.
- The correlation between MPV and stenosis severity is more pronounced in diabetic patients.
- MPV may serve as a useful biomarker for assessing coronary artery disease severity, particularly in diabetic individuals.
Subject:
To investigate the correlation between mean platelet volume (MPV) levels and Gensini scores in stable coronary heart disease (CHD) patients with or without diabetes.
Methods:
A retrospective analysis was conducted on 2525 patients with stable CHD in Zhongshan Hospital, Fudan University. There were 1274 in the low MPV group and 1251 in the high MPV group, divided by a median MPV level of 10.9 fL. In the total population, 1605 patients were non-diabetic and 920 were diabetic. The severity of coronary artery disease was quantified using the Gensini score.
Results:
The Gensini score was significantly higher in the high MPV group than in the low MPV group (p < 0.001). MPV levels increased significantly with the number of stenotic (>50%) coronary vessels (p < 0.001). The Spearman analysis showed a positive correlation between MPV and Gensini score (r = 0.189, p < 0.001), which was more significant in the diabetic subgroup (r = 0.232, p < 0.001). Receiver operating characteristic (ROC) curves were employed to assess the predictive value of MPV for high Gensini scores, using the median value of 32 points as the cutoff. MPV levels in the diabetes cohort exhibited a higher predictive value for high Gensini scores (area under the curve: 0.635 [0.614-0.657], p < 0.001). Multivariate linear regression analysis showed that diabetes and MPV were independently associated with Gensini scores.
Conclusion:
MPV levels in stable CHD patients can predict the severity of coronary artery stenosis. This correlation is more significant in the presence of diabetes.
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