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An overview on viral interference during SARS-CoV-2 pandemic
Luigi Matera1, Sara Manti2, Laura Petrarca1
1Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Frontiers in Pediatrics
|January 5, 2024
Summary
Respiratory viruses cause significant pediatric illness. Viral interference, interactions between coinfecting viruses like SARS-CoV-2 and seasonal ones, impacts disease severity and public health strategies.
Area of Science:
- Pediatrics
- Virology
- Epidemiology
Background:
- Respiratory viruses are a leading cause of pediatric mortality, morbidity, and healthcare costs.
- Viral interference, interactions between coinfecting viruses, influences disease outcomes.
- The emergence of SARS-CoV-2 has heightened concerns about virus-virus interactions.
Purpose of the Study:
- To review research on respiratory virus interference.
- To discuss recent advances in understanding viral interference.
- To examine the impact of SARS-CoV-2 co-circulation with seasonal respiratory viruses.
Main Methods:
- Narrative review of existing literature.
- Analysis of recent advances in respiratory virus interference research.
- Discussion of clinical, diagnostic, and therapeutic implications.
Main Results:
- Co-circulation of SARS-CoV-2 and seasonal respiratory viruses raises concerns about complex interactions.
- These interactions may alter epidemic dynamics, affecting disease course, severity, and targeted populations.
- Climatic conditions and social behaviors may also play a role in these interactions.
Conclusions:
- Prospective epidemiologic studies and mathematical modeling are crucial.
- Predicting the timing and magnitude of SARS-CoV-2/seasonal respiratory virus epidemics is needed.
- Improved public health interventions require a better understanding of these viral interactions.
Keywords:
COVID-19RSVSARS-CoV-2influenzarespiratory syncytial virusrespiratory virusesviral interferenceMore Related Videos
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