Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Proteomics01:33

Proteomics

7.3K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
7.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Breastfeeding in infancy confers sex-specific, long-term protection against metabolic dysfunction-associated steatohepatitis and adverse liver outcomes.

Biology of sex differences·2026
Same author

Instrumental variable estimation of a hazard ratio for treatment with a waiting time without specifying its dependence on unmeasured confounders: application to a procedural registry.

Lifetime data analysis·2026
Same author

Artificial human stem cell niche created in cartilage-inspired hydrogel for enhanced articular cartilage regeneration.

Biomaterials·2026
Same author

Noninvasive Salivary Ketone Monitoring: A Ratiometric Pdot Biosensor toward Personalized Ketogenic Management.

Nano letters·2026
Same author

NanoSSL: attention mechanism-based self-supervised learning method for protein identification using nanopores.

Bioinformatics (Oxford, England)·2026
Same author

Artifactual Sequence Variant Induced by Nonspecific Cleavage-Linked Transpeptidation in Peptide Mapping.

Analytical chemistry·2025

Related Experiment Video

Updated: Jul 6, 2025

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
08:08

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

Published on: February 27, 2015

16.2K

Proteomics: A new dimension to decode small cell lung cancer.

Haobin Chen1, Benjamin J Drapkin2, John D Minna2

  • 1Division of Oncology, Department of Medicine, Washington University in Saint Louis, St Louis, MO, USA.

Cell
|January 5, 2024
PubMed
Summary

Researchers mapped the proteomic and phosphoproteomic features of small cell lung cancer (SCLC) tumors. This detailed biological insight reveals new potential vulnerabilities for treating this challenging cancer.

More Related Videos

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
10:37

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

12.0K
Phosphopeptide Enrichment Coupled with Label-free Quantitative Mass Spectrometry to Investigate the Phosphoproteome in Prostate Cancer
12:23

Phosphopeptide Enrichment Coupled with Label-free Quantitative Mass Spectrometry to Investigate the Phosphoproteome in Prostate Cancer

Published on: August 2, 2018

12.2K

Related Experiment Videos

Last Updated: Jul 6, 2025

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
08:08

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

Published on: February 27, 2015

16.2K
Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
10:37

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

12.0K
Phosphopeptide Enrichment Coupled with Label-free Quantitative Mass Spectrometry to Investigate the Phosphoproteome in Prostate Cancer
12:23

Phosphopeptide Enrichment Coupled with Label-free Quantitative Mass Spectrometry to Investigate the Phosphoproteome in Prostate Cancer

Published on: August 2, 2018

12.2K

Area of Science:

  • Oncology
  • Molecular Biology
  • Proteomics

Background:

  • Small cell lung cancer (SCLC) remains a difficult-to-treat malignancy.
  • Understanding the molecular underpinnings of SCLC is crucial for developing effective therapies.

Purpose of the Study:

  • To comprehensively analyze the proteomic and phosphoproteomic profiles of resected SCLC tumors.
  • To identify novel molecular vulnerabilities in SCLC based on proteomic data.

Main Methods:

  • Proteomic analysis of SCLC tumor samples.
  • Phosphoproteomic analysis of SCLC tumor samples.

Main Results:

  • Detailed proteomic and phosphoproteomic landscapes of SCLC tumors were generated.
  • The study identified specific molecular targets and pathways associated with SCLC.

Conclusions:

  • The proteomic and phosphoproteomic data provide a valuable resource for SCLC research.
  • This knowledge can guide the development of new therapeutic strategies targeting identified SCLC vulnerabilities.