Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Self-Presentation: Self-Monitoring and Self-Handicapping02:05

Self-Presentation: Self-Monitoring and Self-Handicapping

44.8K
People can go to great lengths to protect their self-image and present themselves in ways that they want others to see them. Sociologist Erving Goffman presented the idea that a person is like an actor on a stage. Calling his theory dramaturgy, Goffman believed that we use “impression management” to present ourselves to others as we hope to be perceived. Each situation is a new scene, and individuals perform different roles depending on who is present (Goffman, 1959). Think about...
44.8K
Salivary Glands and Saliva01:23

Salivary Glands and Saliva

2.6K
The salivary glands, of which there are three pairs known as the parotid, submandibular, and sublingual glands, play a crucial role in maintaining oral health and initiating the digestive process. Positioned near the ears, beneath the masseter muscle, the parotid glands secrete saliva into the oral cavity through the parotid duct of Stensen. Meanwhile, the submandibular glands, located on the floor of the mouth, secrete saliva through channels named submandibular ducts. The sublingual glands,...
2.6K
Personal Identity01:25

Personal Identity

472
Personal identity is the deeply felt sense of self that individuals cultivate over time, intricately woven from intrinsic qualities they consider essential to their existence—qualities such as morality, intelligence, and friendliness. These attributes serve as vital internal benchmarks, guiding individuals in evaluating whether their actions resonate with their true selves.When personal identity takes center stage in one's life, individuals often emphasize their distinctiveness,...
472
Structures of Aldehydes and Ketones01:04

Structures of Aldehydes and Ketones

12.3K
Vanillin—a flavoring agent in vanilla, cinnamaldehyde—a molecule responsible for the distinct smell of cinnamon, and acetone—a strong-smelling ingredient in nail polish removers, all belong to a class of carbonyl compounds called aldehydes and ketones (Figure 1). Although both aldehydes and ketones contain the characteristic carbonyl (C=O) bond, their chemical structures vary with respect to the groups directly attached to the carbonyl carbon.
In aldehydes (Figures 1a and 1b), the...
12.3K
Psychodynamic Perspectives on Personality01:27

Psychodynamic Perspectives on Personality

1.6K
The psychodynamic perspective in psychology asserts that most personality functions operate unconsciously, outside of awareness. This means that the motives and emotions driving behavior often remain hidden, automatically buried in the unconscious mind as a defense mechanism to shield us from psychological distress. According to this theory, the unconscious mind contains thoughts, memories, and emotions that are too disturbing to face directly.
Psychodynamic theorists argue that unconscious...
1.6K
Self-Report Tests of Personality01:22

Self-Report Tests of Personality

886
Self-report inventories are objective personality assessments that use multiple-choice items or numbered scales, typically ranging from 1 (strongly disagree) to 5 (strongly agree). They are often called Likert scales after Rensis Likert. These inventories are widely used due to their ease of administration and cost-effectiveness. One of the most prominent examples is the Minnesota Multiphasic Personality Inventory (MMPI), initially developed in the 1940s to assess abnormal personality traits.
886

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

α<sub>1A</sub>-adrenergic receptor activation ameliorates fragmented spatial exploration by improving astrocyte-neuronal coupling in the medial entorhinal cortex of Alzheimer's disease mice.

Neurobiology of disease·2026
Same author

Visible-Light Driven Implantable Nanophotonic Biosensor for Continuous Glucose Monitoring via Metalloporphyrin Q-Band Modulation and Enzymatic Cascade Stabilization.

ACS sensors·2026
Same author

Densely Fluorinated Polymer Dots with Peak Absorption beyond 1000 nm for High-Contrast NIR-II Fluorescence Imaging.

Nano letters·2026
Same author

Astrocytic α7-nicotinic acetylcholine receptors mediate pain information processing and perception.

Neurobiology of disease·2025
Same author

Medical Dressing with Semiconducting Polymer Dots for Photocatalytic Hydrogen Evolution and Diabetic Wound Healing.

ACS applied materials & interfaces·2025
Same author

Astrocytes in the medial entorhinal cortex are required for spatial exploration.

Cell reports·2025

Related Experiment Video

Updated: Feb 14, 2026

Author Spotlight: Advancing Mitochondrial Research - mtHyper7 Biosensor for Subcellular Analysis
09:47

Author Spotlight: Advancing Mitochondrial Research - mtHyper7 Biosensor for Subcellular Analysis

Published on: June 2, 2023

3.4K

Noninvasive Salivary Ketone Monitoring: A Ratiometric Pdot Biosensor toward Personalized Ketogenic Management.

Mingyue Gong1, Zhuli Wu2, Shiyu Wang1

  • 1Department of Biomedical Engineering, Xiangya School of Basic Medical Sciences, Central South University, Changsha, Hunan 410013, China.

Nano Letters
|February 13, 2026
PubMed
Summary

A novel biosensor detects salivary β-Hydroxybutyrate (BHB), a key metabolic biomarker, enabling personalized ketogenic diet management and disease monitoring. This rapid, noninvasive method offers real-time insights into metabolic health.

Keywords:
metabolite biosensornoninvasive monitoringpolymer dotratiometric fluorescenceβ-hydroxybutyrate

More Related Videos

Ratiometric Biosensors that Measure Mitochondrial Redox State and ATP in Living Yeast Cells
12:22

Ratiometric Biosensors that Measure Mitochondrial Redox State and ATP in Living Yeast Cells

Published on: July 22, 2013

21.7K
Monitoring Kinase and Phosphatase Activities Through the Cell Cycle by Ratiometric FRET
13:38

Monitoring Kinase and Phosphatase Activities Through the Cell Cycle by Ratiometric FRET

Published on: January 27, 2012

14.7K

Related Experiment Videos

Last Updated: Feb 14, 2026

Author Spotlight: Advancing Mitochondrial Research - mtHyper7 Biosensor for Subcellular Analysis
09:47

Author Spotlight: Advancing Mitochondrial Research - mtHyper7 Biosensor for Subcellular Analysis

Published on: June 2, 2023

3.4K
Ratiometric Biosensors that Measure Mitochondrial Redox State and ATP in Living Yeast Cells
12:22

Ratiometric Biosensors that Measure Mitochondrial Redox State and ATP in Living Yeast Cells

Published on: July 22, 2013

21.7K
Monitoring Kinase and Phosphatase Activities Through the Cell Cycle by Ratiometric FRET
13:38

Monitoring Kinase and Phosphatase Activities Through the Cell Cycle by Ratiometric FRET

Published on: January 27, 2012

14.7K

Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Metabolomics

Background:

  • β-Hydroxybutyrate (BHB) is a crucial ketone body and metabolic biomarker.
  • Accurate BHB monitoring is vital for ketogenic diet management and metabolic disease screening.
  • Current detection methods can be invasive or lack real-time capabilities.

Purpose of the Study:

  • To develop a rapid, noninvasive biosensor for salivary BHB detection.
  • To enable personalized metabolic monitoring and early disease screening.
  • To utilize semiconducting polymer dots (Pdots) for sensitive BHB quantification.

Main Methods:

  • An NADH-responsive semiconducting polymer dot (Pdot) biosensor was designed.
  • Enzymatic catalysis converted BHB to NADH, triggering a ratiometric fluorescence signal (I470/I650).
  • The sensor was validated in solution, paper-based formats, and dynamic monitoring in volunteers using smartphone imaging.

Main Results:

  • The Pdot biosensor demonstrated an exponential correlation between the ratiometric signal and BHB concentration.
  • The sensor achieved precise, real-time, and noninvasive detection of salivary BHB.
  • Both solution- and paper-based assays provided rapid and low-cost analysis.

Conclusions:

  • The developed ratiometric Pdot fluorescence sensor offers a precise method for noninvasive BHB detection.
  • This technology supports real-time metabolic health monitoring and personalized dietary interventions.
  • The sensor is suitable for early metabolic-disease screening and management.