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Reliability of blood eosinophil count in steady-state bronchiectasis
M A Martínez-García1,2, C Olveira3, R Girón4
1Servicio de Neumología, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
Pulmonology
|January 5, 2024
Summary
Baseline blood eosinophil counts (BEC) in bronchiectasis patients fluctuate significantly over time. Regular monitoring of BEC is crucial for accurate assessment of disease severity and treatment response.
Area of Science:
- Pulmonology
- Clinical Medicine
- Biomarker Research
Background:
- Baseline blood eosinophil counts (BEC) are linked to bronchiectasis severity, prognosis, and treatment response.
- The long-term stability of baseline BEC in bronchiectasis patients remains unestablished.
Purpose of the Study:
- To determine if baseline BEC remains stable over extended periods in individuals with bronchiectasis.
Main Methods:
- Utilized data from the RIBRON registry, including patients with at least two BEC measurements a year apart.
- Excluded patients with asthma or those on anti-eosinophilic medications.
- Assessed reliability using intra-class correlation coefficient (ICC) and analyzed changes in eosinophilic/eosinopenic status.
Main Results:
- Seven hundred thirteen patients were analyzed with a median of 4 BEC measurements per patient.
- Good ICC (>0.75) was observed between consecutive annual measurements, but it decreased significantly thereafter.
- Over 30% of patients shifted from eosinophilic/eosinopenic status within the first year, increasing to nearly 50% in subsequent measurements.
Conclusions:
- Baseline BEC values in bronchiectasis patients exhibit significant variability over time.
- Continuous monitoring of BEC is recommended for reliable assessment of its clinical utility in managing bronchiectasis.
