Related Experiment Video
Updated: Jul 6, 2025
Construction and Characterization of a Novel Vocal Fold Bioreactor
Published on: August 1, 2014
Histologic Evaluation of Silk-Hyaluronic Acid After Human Vocal Fold Injection
Sophie E Yu1, Elliana K DeVore2, Thomas L Carroll3
1Department of Otolaryngology-Head and Neck Surgery, Harvard Medical School, Boston, Massachusetts.
Objectives:
This case report aims to histologically examine human vocal fold tissue 9 months after silk-hyaluronic acid (silk-HA) injection.
Introduction:
Silk-HA is an engineered injectable implant made from natural protein biomaterial, silk, crosslinked with hyaluronic acid to provide long-lasting, dynamic office-based vocal fold injection augmentation to restore glottic competency.
Methods:
We report the case of an adult female with left vocal fold immobility and bilateral atrophy that was treated with silk-HA injections with biopsy taken 9 months after injection for histological examination.
Conclusion:
Silk-HA injection in human true vocal fold demonstrates slow degradation of particles and intended cellular infiltration 9 months after injection.
