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Published on: June 4, 2020
Fibrinogen as a potential diagnostic marker for prediction and evaluation of postpartum hemorrhage: a retrospective
Yanke Zou1, Yixiao Jiang1, Dawei Zhu1
1Department of Cardiology, Daping Hospital, Army Military Medical University, Chongqing, China.
Objective:
To investigate whether prenatal fibrinogen (FIB) or other related factors could be utilized to evaluate the risk of postpartum hemorrhage (PPH).
Methods:
A retrospective study was conducted in a database from January 2015 to December 2019. A total of 128 patients were enrolled and evaluated with FIB, in which 55 patients were assigned to low FIB and 73 in normal FIB.
Results:
According to the volume of blood loss, the mean of the low FIB group (<4 g/L) was markedly higher than that of the normal FIB group (≥4 g/L). Prenatal FIB was negatively correlated with PPH volume. The receiver operating characteristic (ROC) curve results indicated that the value of prenatal FIB was 0.701 to predict refractory PPH.
Conclusions:
Prenatal FIB was significantly related to thrombin time (TT), which may be an independent factor to predict the coagulation state of prenatal pregnancy.
