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Microbiome and its implications in oncogenesis: a Mendelian randomization perspective.

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American Journal of Cancer Research
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The human microbiome influences cancer development. Mendelian Randomization (MR) offers a robust method to explore these causal links, overcoming limitations of traditional studies.

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Mendelian randomizationMicrobiomecancer

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Area of Science:

  • Microbiology
  • Oncology
  • Genetics

Background:

  • The human microbiome plays a crucial role in oncogenesis.
  • The intestinal tract is a primary habitat for microbes linked to cancer.
  • Microbial disturbances are associated with cancer progression.

Purpose of the Study:

  • To explore the complex relationship between the microbiome, its metabolites, and cancer.
  • To highlight the limitations of traditional causality assessment methods like RCTs.
  • To advocate for Mendelian Randomization (MR) as a superior method for studying microbiome-cancer causality.

Main Methods:

  • Systematic review of Mendelian Randomization (MR) studies.
  • Utilizing genetic variants as instrumental variables to infer causality.
  • Discussing the integration of multi-omics data (genomics, transcriptomics, proteomics, metabolomics).

Main Results:

  • Mendelian Randomization (MR) provides a powerful approach to investigate causal relationships in microbiome-cancer research.
  • Specific bacterial strains are implicated in cancers like stomach and colorectal cancer.
  • MR helps address confounding factors such as diet and lifestyle.

Conclusions:

  • The human microbiome is critical in oncogenesis.
  • Mendelian Randomization (MR) is an indispensable tool for advancing microbiome-cancer research.
  • Integrating multi-omics data with MR promises future breakthroughs.