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Related Concept Videos

Brain Imaging01:14

Brain Imaging

234
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
234

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Related Experiment Video

Updated: Jul 6, 2025

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment
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Neural Interoceptive Processing is Modulated by Deep Brain Stimulation for Treatment Resistant Depression.

Elisa Xu, Samantha Pitts, Jacob Dahill-Fuchel

    Biorxiv : the Preprint Server for Biology
    |January 8, 2024
    PubMed
    Summary
    This summary is machine-generated.

    Deep brain stimulation (DBS) for treatment-resistant depression (TRD) enhanced heartbeat-evoked potential (HEP) amplitude, suggesting interoception plays a role in treatment efficacy. This finding links brain activity to depression treatment outcomes.

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    Area of Science:

    • Neuroscience
    • Psychiatry
    • Medical Engineering

    Background:

    • Depression research is advancing to understand how interoceptive processing influences treatment effectiveness.
    • This study investigates if deep brain stimulation (DBS) of the subcallosal cingulate (SCC) impacts cortical interoceptive processing, measured by the heartbeat-evoked potential (HEP), in treatment-resistant depression (TRD).

    Approach:

    • Eight TRD patients underwent SCC DBS, with electroencephalography (EEG) and symptom severity assessed over six months.
    • The primary outcome was the EEG-derived HEP, reflecting cortical processing of heartbeat sensation.
    • Cluster-based permutation analyses examined the effects of stimulation and treatment duration on HEP, correlating changes with depression severity (17-item Hamilton Depression Rating Scale).

    Key Points:

    • After 24 weeks of SCC DBS treatment, HEP amplitude significantly increased (t(7)=-4.40, p=.003), correlating inversely with treatment response latency (rho = -0.75, p=.03).
    • An acute effect of DBS also decreased HEP amplitude (t(6) = 6.66, p <.001).
    • HEP changes were most prominent over left posterior sensors between 405-425 ms post-stimulus.

    Conclusions:

    • This study provides brain-based evidence supporting the link between interoception and depression.
    • Findings suggest that interoceptive mechanisms contribute to the efficacy of deep brain stimulation for severe depression.