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Acantholytic Squamous Cell Carcinoma: a Diagnostic Pitfall on Cytology
Md Ali Osama1, Kavita Gaur1, Priti Chatterjee1
1Department of Pathology, Lady Hardinge Medical College, New Delhi, 110001 India.
Acantholytic squamous cell carcinoma of the penis is rare, with limited data on its pathology and prognosis. This case highlights diagnostic challenges in metastatic lymph nodes.
Area of Science:
- Oncology
- Pathology
- Cytopathology
Background:
- Acantholytic squamous cell carcinoma (ASCC) is a rare subtype of squamous cell carcinoma.
- ASCC is infrequently described in the penile location, limiting available data on its characteristics.
Observation:
- This study presents a case of metastatic ASCC to an inguinal lymph node.
- The primary penile lesion presented a diagnostic challenge on cytological examination.
Findings:
- The case underscores the aggressive biologic behavior observed in ASCC.
- Limited information exists regarding the pathological and immunohistochemical findings of penile ASCC.
Implications:
- Pathologists must be aware of ASCC's cytological features for accurate diagnosis.
- Distinguishing ASCC from conventional squamous cell carcinoma is crucial for appropriate patient management.
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