Fabricating the multibranch carboxyl-modified cellulose for hemorrhage control
Shengyu Li1, Lihong Gong2, Jianglin Chen3
1The Second Affiliated Hospital & Second Clinical Medical School, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Materials Today. Bio
|January 8, 2024
Summary
A novel hemostatic material, MCAA, derived from microcrystalline cellulose, effectively controls bleeding by promoting platelet aggregation and activating the clotting cascade. This safe and biocompatible agent shows significant potential for hemorrhage control.
Area of Science:
- Biomaterials Science
- Hemostasis Research
- Nanotechnology
Background:
- Excessive bleeding poses a significant mortality risk.
- Developing effective hemostatic agents is crucial for managing hemorrhage.
- Modifying cellulose surfaces can enhance biomaterial properties.
Purpose of the Study:
- To investigate the hemostatic potential of microcrystalline cellulose modified with citric and ascorbic acids (MCAA).
- To characterize the properties and biocompatibility of MCAA.
- To elucidate the hemostatic mechanisms of MCAA.
Main Methods:
- Sequential modification of microcrystalline cellulose with citric and ascorbic acids.
- Characterization using FT-IR, TGA, and XPS.
- In vitro hemocompatibility, cytotoxicity, and hemostatic assays.
- In vivo assessment in tail-amputation and liver-injury hemorrhage models.
Main Results:
- MCAA exhibited a high carboxyl content (9.52%) and enhanced thermal stability.
- MCAA demonstrated excellent biocompatibility (hemolysis <1%) and cell compatibility (viability >100%).
- Significant hemostatic effect observed in vitro (BCI=31.3%) and in vivo models.
- MCAA accelerated coagulation via platelet aggregation and clotting cascade activation.
Conclusions:
- MCAA is a safe and effective hemostatic agent for hemorrhage control.
- The carboxyl functionalization of cellulose enhances its hemostatic properties.
- MCAA shows promise for clinical applications in wound management and bleeding control.
