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Updated: Jun 10, 2026

Array Comparative Genomic Hybridization (Array CGH) for Detection of Genomic Copy Number Variants
09:16

Array Comparative Genomic Hybridization (Array CGH) for Detection of Genomic Copy Number Variants

Published on: February 21, 2015

Array-Based Comparative Genomic Hybridization for the Detection of Copy Number Alterations in Single Cells

Giancarlo Feliciello1, Zbigniew Tadeusz Czyz2, Bernhard M Polzer3

  • 1Cellular and Molecular Diagnostics Group, Division of Personalized Cancer Therapy, Fraunhofer Institute of Toxicology and Experimental Medicine ITEM-R, Regensburg, Germany. giancarlo.feliciello@item.fraunhofer.de.

Methods in Molecular Biology (Clifton, N.J.)
|January 9, 2024
PubMed
Summary

This study presents a robust array-based comparative genomic hybridization (aCGH) protocol for analyzing single cancer cell genomes. The method reliably detects copy number alterations (CNAs) crucial for cancer research and diagnostics.

Keywords:
Array hybridizationCNAsPCR labelingSingle cellsaCGH

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