Endothelial cell loss post-implantable collamer lens V4c: meta-analysis

Area of Science:

• Ophthalmology
• Biomaterials Science

Background:

• Endothelial cell density (ECD) loss is a known complication of implantable collamer lens (ICL) V4c surgery for myopia correction.
• Existing literature presents varied ECD loss data, complicating patient and clinician guidance.

Approach:

• A meta-analysis was conducted on 18 studies evaluating ECD loss following ICL V4c implantation.
• Subgroup analyses were performed based on follow-up durations to address data variability.

Key Points:

• Average ECD loss was 1.32% at 3 months, 1.75% at 12 months, and 3.84% at a mean of 21.25 months post-surgery.
• The most substantial ECD loss occurred within the initial 3 months, indicating acute surgical trauma as the primary factor.
• ECD loss with ICL V4c is comparable to other ICL models, suggesting consistent safety profiles.

Conclusions:

• ICL V4c surgery for myopia correction demonstrates a predictable pattern of endothelial cell density loss.
• The findings affirm the overall safety of the ICL V4c model in terms of endothelial cell health.