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Related Experiment Video

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Protein sensing using deep subwavelength-engineered photonic crystals.

Yanrong Zhang, Christopher S Whittington, Rabeb Layouni

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    We enhanced protein detection sensitivity using a novel silicon photonic crystal nanobeam cavity. This deep subwavelength design boosts light-molecule interaction for significantly improved biosensing performance.

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    Area of Science:

    • Nanophotonics
    • Biophotonics
    • Optical biosensing

    Background:

    • Photonic crystal nanobeam (PhCNB) cavities are used for biosensing.
    • Enhancing light-molecule interactions is key to improving sensitivity.

    Purpose of the Study:

    • To develop a PhCNB cavity with higher sensitivity for protein detection.
    • To investigate the effect of a deep subwavelength feature on light energy density and sensing performance.

    Main Methods:

    • Fabrication and characterization of a silicon antislot PhCNB cavity.
    • Comparison of sensing capabilities between engineered and traditional PhCNB cavities using simulations and experiments.
    • Protein binding assays using streptavidin-biotin interactions.

    Main Results:

    • The engineered antislot PhCNB cavity locally enhances light energy density.
    • This enhancement leads to stronger light-molecule interactions at the cavity surface.
    • Experiments showed a nearly 50% larger resonance shift upon protein attachment compared to traditional cavities.

    Conclusions:

    • Deep subwavelength engineering of PhCNB cavities significantly improves protein detection sensitivity.
    • The antislot feature enables enhanced surface-based light-molecule interactions for superior biosensing.
    • This approach offers a promising pathway for developing next-generation optical biosensors.