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Related Concept Videos

Assessment of the Mouth01:26

Assessment of the Mouth

A thorough mouth assessment, including inspection and palpation of the lips, gums, tongue, tonsils, uvula, and pharynx, is crucial in detecting potential health issues. Diseases ranging from oral cancer to systemic conditions like diabetes could be identified early through careful oral examination. This article provides a detailed guide on conducting a comprehensive mouth assessment.
Mouth Inspection
The inspection begins with visually examining the mouth for symmetry, color, and size.
Microbial Morphologies01:29

Microbial Morphologies

Bacterial and archaeal cells exhibit remarkable diversity in shape and structure, critical in their adaptability and functionality. Among bacteria, the most commonly observed shapes include cocci and bacilli. Cocci are spherical and may exist singly or in groupings such as pairs (diplococci), chains (streptococci), clusters (staphylococci), or tetrads. Bacilli, in contrast, are rod-shaped and can also occur as single cells, in pairs, or chains, depending on their environmental and genetic...
Methods to Assess Microbial Populations01:30

Methods to Assess Microbial Populations

Assessing microbial populations is crucial for understanding microbial roles in health, ecology, and industry. Various complementary techniques—both culture-based and molecular—enable detailed analysis of microbial abundance, diversity, and function.Viable Plate CountThe viable plate count is a traditional culture-based method used to estimate the number of living microbes in a sample. After serial dilution, the sample is spread onto nutrient agar plates. Each viable cell forms a visible...
Methods to Assess Microbial Communities01:19

Methods to Assess Microbial Communities

Microbial communities, comprising bacteria, archaea, and eukaryotic microorganisms, inhabit diverse ecosystems and play crucial roles in environmental and biological processes. Their diversity is defined by three main parameters: species richness (the number of distinct species), species abundance (the relative quantity of each species), and species evenness (how uniformly individual species are distributed in various locations). These factors together shape the structure and ecological balance...
The Oral Microbiota01:27

The Oral Microbiota

The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
Development of the Oral Microbiota01:28

Development of the Oral Microbiota

The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...

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Related Experiment Video

Updated: Jul 5, 2026

Oral Biofilm Analysis of Palatal Expanders by Fluorescence In-Situ Hybridization and Confocal Laser Scanning Microscopy
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Omics for deciphering oral microecology.

Yongwang Lin1, Xiaoyue Liang1, Zhengyi Li1

  • 1State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

International Journal of Oral Science
|January 9, 2024
PubMed
Summary
This summary is machine-generated.

Technological advances are revolutionizing oral microbiome research, enabling detailed analysis of microbial communities for improved oral and systemic health. Future integration promises to transform disease prediction and treatment.

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Oral Biofilm Analysis of Palatal Expanders by Fluorescence In-Situ Hybridization and Confocal Laser Scanning Microscopy
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Area of Science:

  • Microbiology
  • Genomics
  • Biotechnology

Background:

  • The human oral microbiome is a complex and diverse community vital for oral and systemic health.
  • Technological advancements are enhancing our ability to study and manipulate oral microbiota.

Purpose of the Study:

  • To review recent technological innovations for oral microbiome characterization and manipulation.
  • To highlight the potential of integrated technologies for understanding oral health and disease.

Main Methods:

  • High-throughput sequencing for taxonomic and functional profiling.
  • Long-read sequencing for improved genome assembly.
  • Single-cell genomics for uncultured taxa.
  • Advanced imaging (fluorescence, mass spectrometry, Raman spectroscopy) for spatial and metabolic insights.
  • Culturomics for isolating novel oral taxa.

Main Results:

  • These technologies offer high-resolution visualization of microbial organization and interactions.
  • They provide insights into metabolic activities, biomolecular fingerprints, and uncultured microbes.
  • Integration promises to transform understanding of microbiome assembly, gene expression, and microbe-host interactions.

Conclusions:

  • Significant knowledge gaps remain regarding oral microbiome origins, development, and therapeutic manipulation.
  • The convergence of sequencing, imaging, culturomics, and synthetic models will advance oral microbiome research.
  • This integration offers opportunities for predicting, preventing, diagnosing, and treating oral diseases.