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Updated: Jun 18, 2026
Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Published on: August 25, 2014
Time to regain birthweight and association with neurodevelopmental outcomes among extremely preterm newborns
Gregory C Valentine1,2, Krystle M Perez3, Thomas R Wood3
1Division of Neonatology, University of Washington/Seattle Children's Hospital, Seattle, WA, USA. gcvalent@uw.edu.
Objective:
Determine association between time to regain birthweight and 2-year neurodevelopment among extremely preterm (EP) newborns.
Study Design:
Secondary analysis of the Preterm Erythropoietin Neuroprotection Trial evaluating time to regain birthweight, time from birth to weight nadir, time from nadir to regain birthweight, and cumulative weight loss with 2-year corrected Bayley Scales of Infant and Toddler Development 3rd edition.
Results:
Among n = 654 EP neonates, those with shorter nadir-to-regain had lower cognitive scores (≤1 day versus ≥8 days: -5.0 points, [CI -9.5, -0.6]) and lower motor scores (≤1 day versus ≥8 days: -4.6 points [CI -9.2, -0.03]) in adjusted stepwise forward regression modeling. Increasingly cumulative weight loss was associated with lower cognitive scores (≤-50 percent-days: -5.6, [CI -9.4, -1.8]), motor scores (≤-50 percent-days: -4.2, [CI -8.2, -0.2]); and language scores (≤-50 percent-days: -6.0, [CI -10.1, -1.9]).
Conclusion:
Faster nadir-to-regain and excessive cumulative weight loss are associated with adverse 2-year neurodevelopmental outcomes.
Trial Registration:
PENUT Trial Registration: NCT01378273. https://clinicaltrials.gov/ct2/show/NCT01378273 .
Clinical Trial Registration:
This study is a post-hoc secondary analysis of pre-existing data from the PENUT Trial (NCT #01378273).
