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Association between intestinal microflora and renal function in patients with chronic renal failure: A case-control
Haixia Chen1, Xiaoxiao Xie2, Shuming Tang3
1Haixia Chen, Department of Clinical Laboratory, Shenzhen People's, Hospital the Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, Guangdong Province 518020, China.
Pakistan Journal of Medical Sciences
|January 10, 2024
Summary
Changes in gut bacteria are linked to worse kidney function in chronic renal failure (CRF) patients. An imbalance in intestinal microflora may accelerate kidney damage.
Area of Science:
- Nephrology
- Microbiology
- Gastroenterology
Background:
- Chronic renal failure (CRF) is a progressive condition affecting kidney function.
- The gut microbiome plays a crucial role in overall health and disease.
- Alterations in gut microbiota have been implicated in various systemic diseases.
Purpose of the Study:
- To investigate the association between intestinal microflora composition and renal function parameters in patients with CRF.
- To compare the gut microbial profiles of CRF patients with healthy individuals.
Main Methods:
- A retrospective case-control study involving 50 CRF patients and 50 healthy controls.
- Analysis of intestinal microflora distribution.
- Measurement of glomerular filtration rate (GFR), serum creatinine (SCr), blood urea nitrogen (BUN), and serum cystatin C (CysC).
Main Results:
- CRF patients exhibited higher levels of Enterococci and lower levels of Bifidobacterium spp. and Escherichia coli compared to controls.
- CRF patients showed significantly lower GFR and higher levels of BUN, SCr, and CysC.
- Renal function indicators (GFR, BUN, SCr, CysC) correlated negatively with Bifidobacterium spp. and Lactobacillus spp., and positively with Enterococcus spp. and Escherichia coli.
Conclusions:
- Intestinal microflora alterations are associated with decreased GFR and increased serum renal function markers in CRF.
- Imbalances in gut microbiota may contribute to the progression of renal function damage in CRF patients.
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