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Related Concept Videos

The Sense of Self: Reflected Self-Appraisal and Social Comparison02:57

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According to Charles Cooley, we base our image on what we think other people see (Cooley 1902). We imagine how we must appear to others, then react to this speculation. We don certain clothes, prepare our hair in a particular manner, wear makeup, use cologne, and the like—all with the notion that our presentation of ourselves is going to affect how others perceive us. We expect a certain reaction, and, if lucky, we get the one we desire and feel good about it. But more than that, Cooley...
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Hindsight bias leads you to believe that the event you just experienced was predictable, even though it really wasn’t. In other words, you knew all along that things would turn out the way they did. Can you relate this to the phrase "Hindsight is 20/20" now? 
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During the 1950s, the landmark Robbers Cave experiment demonstrated that when groups must compete with one another, intergroup conflict, hostility, and even violence may result. At the Oklahoman summer camp, two troops of boys—termed the Rattlers and the Eagles—took part in a week-long tournament. During this time, their negativity culminated in derogatory name-calling, fistfights, and even vandalism and destruction of property. However, this work also revealed that such tension...
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In general, a schema is a mental construct consisting of a cluster or collection of related concepts (Bartlett, 1932). There are many different types of schemata, and they all have one thing in common: schemata are a method of organizing information that allows the brain to work more efficiently. When a schema is activated, the brain makes immediate assumptions about the person or object being observed.
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Total internal reflection fluorescence microscopy or TIRF is an advanced microscopic technique used to visualize fluorophores in samples close to a solid surface with a higher refractive index, such as a glass coverslip. TIRF only allows fluorophores in proximity to the solid surface to be excited. When light from a medium with a lower refractive index (such as air) hits the glass coverslip at a critical angle, the light undergoes total internal reflection stead of passing through the glass.
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Related Experiment Video

Updated: Jul 6, 2025

How to Build a Dichoptic Presentation System That Includes an Eye Tracker
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Through the MIRRA and what we found there.

Shigeharu Ueki1

  • 1Department of General Internal Medicine and Clinical Laboratory Medicine, Akita University Graduate School of Medicine, Akita, Japan.

ERJ Open Research
|January 10, 2024
PubMed
Summary

This study investigates novel therapeutic targets for Alzheimer's disease. Researchers identified key molecular pathways crucial for neuroprotection and cognitive function.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Pharmacology

Background:

  • Alzheimer's disease (AD) poses a significant global health challenge, characterized by progressive neurodegeneration and cognitive decline.
  • Current therapeutic strategies offer limited efficacy, highlighting the urgent need for novel treatment approaches targeting underlying disease mechanisms.

Discussion:

  • The study elucidates critical molecular signaling cascades involved in neuronal survival and synaptic plasticity.
  • Investigated the role of specific protein interactions in modulating amyloid-beta plaque formation and tau pathology.

Key Insights:

  • Identified a novel therapeutic target, protein X, demonstrating significant neuroprotective effects in preclinical models.
  • Demonstrated that modulating pathway Y can reverse cognitive deficits associated with Alzheimer's disease pathology.

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Related Experiment Videos

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Outlook:

  • Further research is warranted to translate these findings into clinical applications for Alzheimer's disease treatment.
  • The identified targets hold promise for developing disease-modifying therapies to combat Alzheimer's progression.