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Sonogenetics for Monitoring and Modulating Biomolecular Function by Ultrasound.

Johannes Hahmann1,2,3, Aman Ishaqat1,2, Twan Lammers4

  • 1Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, Worringerweg 1, 52074, Aachen, Germany.

Angewandte Chemie (International Ed. in English)
|January 10, 2024
PubMed
Summary
This summary is machine-generated.

Sonogenetics uses ultrasound to control cellular functions remotely, offering precise imaging and therapies. This technology overcomes limitations of optogenetics and magnetogenetics for deep tissue manipulation.

Keywords:
Acoustic Reporter GenesBiomolecular FunctionMechanosensitive Ion ChannelsSonogeneticsUltrasound

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Area of Science:

  • Biophysics
  • Molecular Biology
  • Biotechnology

Background:

  • Sonogenetics merges ultrasound, genetic engineering, and chemistry for remote cellular control.
  • It enables precise in vivo imaging and therapeutic interventions by harnessing mechanical forces.
  • This technology offers a significant advantage over optogenetics and magnetogenetics for deep tissue applications.

Purpose of the Study:

  • To review the emerging field of sonogenetics.
  • To discuss current sonogenetic tools and their applications.
  • To explore future directions and challenges in sonogenetics.

Main Methods:

  • Review of literature on mechanosensitive ion channels used in sonogenetics.
  • Overview of sonogenetic approaches utilizing thermal or mechanical ultrasound properties.
  • Exploration of mechanochemically reactive macromolecular systems.
  • Discussion of ultrasound imaging of biomolecular function using gas vesicles and acoustic reporter genes.

Main Results:

  • Mechanosensitive ion channels are key mediators in sonogenetics across various systems.
  • Sonogenetic tools can precisely control cellular functions at depths up to tens of centimeters.
  • Novel approaches leverage thermal/mechanical ultrasound features and mechanochemical systems.
  • Ultrasound imaging of biomolecular function is advancing through gas vesicles and reporter genes.

Conclusions:

  • Sonogenetics is a powerful, non-invasive technology for remote cellular control and deep tissue manipulation.
  • It offers significant potential for advanced biomedical imaging and therapeutic applications.
  • Further research is needed to address current limitations and fully realize the future potential of sonogenetics.