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Elevated atherogenic index of plasma associated with stroke risk in general Chinese

Yijun Zhang1,2,3,4,5, Shuohua Chen6, Xue Tian1,2,3,4,5

  • 1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Endocrine
|January 10, 2024
PubMed

Insights

Elevated atherogenic index of plasma (AIP) is linked to increased stroke and ischemic stroke risk. This association holds for both baseline and long-term measurements in the general population.

Area of Science:

  • Cardiovascular epidemiology
  • Biomarkers of cardiovascular risk

Background:

  • The atherogenic index of plasma (AIP) is a proposed marker for cardiovascular disease (CVD).
  • Limited longitudinal data exists on the association between AIP and stroke risk.

Purpose of the Study:

  • To investigate the association between baseline and long-term AIP levels and the risk of stroke and its subtypes.

Main Methods:

  • Analysis of 97,959 participants from the Kailuan study, stroke-free at baseline.
  • AIP calculated as log(triglyceride/HDL-C); updated mean AIP also computed.
  • Cox proportional hazard models used to assess stroke risk over a median follow-up of 12.79 years.

Main Results:

  • Higher baseline AIP quartiles correlated with increased stroke and ischemic stroke (IS) risk.
  • Multivariate-adjusted HR for stroke in the highest vs. lowest AIP quartile was 1.12.
  • No significant association found between AIP and intracerebral hemorrhage (ICH) risk.

Conclusions:

  • Elevated baseline and long-term AIP are associated with higher risks of stroke and IS.
  • AIP does not appear to be significantly associated with ICH risk in the general population.
Abstract

Keywords:
Atherogenic index of plasmaLongitudinalRisk factorStroke

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