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Inter and intradevice assessment of microperimetry testing in aging eyes
Leonard M Coulibaly1, Hamza Mohamed2, Philipp Fuchs1
1Department of Ophthalmology and Optometry, Vienna Clinical Trial Centre (VTC), Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.
Abstract:
Microperimetry (MP) is a psychometric examination combining retinal imaging and functional sensitivity testing with an increasing importance due to its potential use as clinical study outcome. We investigated the repeatability of pointwise retinal sensitivity (PWS) on the most advanced commercially available MP devices under their standard setting in a healthy aging population. Two successive MP examinations on both MP-3 (NIDEK CO., Ltd., Gamagori, Japan) and MAIA (CenterVue S.p.A. (iCare), Padova, Italy) were performed on healthy aging subjects in a randomized order. PWS repeatability was analysed for different macular regions and age groups using Bland-Altmann coefficients of repeatability (CoR). A total of 3600 stimuli from 20 healthy individuals with a mean age of 70 (11) years were included. Mean CoR in dB were ±4.61 for MAIA and ±4.55 for MP-3 examinations. A lower repeatability (p=0.005) was detected in the central millimetre on MAIA examinations. Higher subject age was associated with a lower repeatability of PWS on both devices (both p=0.003). Intra-device correlation was good (MAIA: 0.79 [0.76-0.81]; MP-3: 0.72 [0.68-0.76]) whereas a moderate mean inter-device correlation (0.6 [0.55-0.65]) could be detected. In conclusion, older subjects and the foveal region are associated with a worse pointwise repeatability.
Insights
Pointwise retinal sensitivity (PWS) repeatability was assessed in healthy aging adults using two microperimetry (MP) devices. Older age and the central macula showed reduced PWS repeatability, impacting clinical study outcomes.
Area of Science:
- Ophthalmology
- Medical Imaging
- Gerontology
Background:
- Microperimetry (MP) combines retinal imaging and sensitivity testing, gaining importance as a clinical study outcome measure.
- Assessing the repeatability of MP is crucial for its reliable application in research and clinical settings.
Purpose of the Study:
- To investigate the repeatability of pointwise retinal sensitivity (PWS) measurements using two advanced microperimetry devices (MP-3 and MAIA).
- To evaluate the influence of age and macular region on PWS repeatability in a healthy aging population.
Main Methods:
- Two successive MP examinations were conducted on 20 healthy aging subjects (mean age 70 years) using MP-3 and MAIA devices in a randomized order.
- Pointwise retinal sensitivity (PWS) repeatability was analyzed using Bland-Altmann coefficients of repeatability (CoR) across different macular regions and age groups.
Main Results:
- Mean CoR values were ±4.61 dB for MAIA and ±4.55 dB for MP-3.
- Lower PWS repeatability was observed in the central millimeter on MAIA (p=0.005) and with increasing age for both devices (p=0.003).
- Good intra-device correlation was found (MAIA: 0.79; MP-3: 0.72), with moderate inter-device correlation (0.6).
Conclusions:
- Older age and the foveal region are associated with worse pointwise retinal sensitivity repeatability in microperimetry.
- These findings highlight factors influencing the reliability of MP measurements in aging populations and for clinical studies.
