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Targeting the Ubiquitin-Proteasome System and Recent Advances in Cancer Therapy
Daniela Spano1, Giuliana Catara2
1Institute for Endocrinology and Experimental Oncology "G. Salvatore", National Research Council, Via Pietro Castellino 111, 80131 Naples, Italy.
Cells
|January 11, 2024
Summary
Ubiquitination, a key protein modification, regulates cellular processes but its dysregulation drives diseases like cancer. Targeting the ubiquitin-proteasome system (UPS) offers new anticancer therapies, though challenges like drug resistance remain.
Area of Science:
- Biochemistry
- Molecular Biology
- Oncology
Background:
- Ubiquitination is a crucial post-translational modification regulating protein function and cellular homeostasis.
- Dysregulation of ubiquitination is implicated in various diseases, including cancer, neurodegenerative disorders, and immune pathologies.
- The ubiquitin-proteasome system (UPS) enzymes, such as E3 ubiquitin ligases and deubiquitinases (DUBs), are recognized as significant targets for therapeutic intervention.
Purpose of the Study:
- To summarize the role of ubiquitination enzymes in tumorigenesis.
- To provide an overview of current and emerging UPS-targeting anticancer therapies.
- To discuss limitations of existing therapies and strategies to overcome them.
Main Methods:
- Literature review of ubiquitination pathways and their role in cancer.
- Analysis of pharmacological interventions targeting the UPS.
- Discussion of drug resistance mechanisms and novel therapeutic technologies.
Main Results:
- Deregulated ubiquitination enzymes contribute to cancer development.
- Several UPS-targeting drugs are in clinical use or trials for cancer treatment.
- Significant challenges exist, including therapeutic efficacy limitations and drug resistance.
Conclusions:
- Targeting the UPS holds promise for novel anticancer strategies.
- Overcoming drug resistance and side effects is crucial for improving therapeutic outcomes.
- Emerging UPS-related technologies offer new avenues for cancer therapeutics.
Keywords:
cancerproteasome-mediated degradationprotein post-translational modificationssynthetic lethalitytherapeutic approachesubiquitinationMore Related Videos
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