Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A scoping review of computational models of the diabetic foot.

PloS one·2026
Same author

An osteoporotic bone model: developing and validating an ex-vivo bone demineralization protocol.

JBMR plus·2026
Same author

Species-Specific Chondrogenesis in Growth Factor-Free Hydrogels: Translational Lessons from Ovine and Human MSCs.

Stem cell reviews and reports·2026
Same author

Development of a mobile 3D printer and comparative evaluation against traditional gantry systems.

Journal of intelligent manufacturing·2025
Same author

Piezoelectric Biomaterials for Bone Regeneration: Roadmap from Dipole to Osteogenesis.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025
Same author

Influence of Cell Seeding Density and Material Stiffness on Chondrogenesis of Human Stem Cells Within Soft Hydrogels, Without the Use of Exogenous Growth Factors.

Gels (Basel, Switzerland)·2025

Related Experiment Video

Updated: Jul 5, 2025

3D Printed Porous Cellulose Nanocomposite Hydrogel Scaffolds
06:36

3D Printed Porous Cellulose Nanocomposite Hydrogel Scaffolds

Published on: April 24, 2019

9.6K

Poly-ε-Caprolactone 3D-Printed Porous Scaffold in a Femoral Condyle Defect Model Induces Early Osteo-Regeneration.

Arianna De Mori1, Aikaterina Karali2, Evangelos Daskalakis3

  • 1School of Pharmacy and Biomedical Sciences, University of Portsmouth, St. Michael's Building, White Swan Road, Portsmouth PO1 2DT, UK.

Polymers
|January 11, 2024
PubMed
Summary

New polycaprolactone (PCL) scaffolds enriched with hydroxyapatite, tricalcium phosphate, or Bioglass promote bone regeneration. PCL-Bioglass showed enhanced bone formation in critical-sized defects.

Keywords:
Bioglassbeta-tricalcium phosphatebone tissue engineeringhydroxyapatitein vivopolycaprolactonethree-dimensional printing

More Related Videos

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold
09:37

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold

Published on: October 23, 2015

12.7K
Novel Process for 3D Printing Decellularized Matrices
08:14

Novel Process for 3D Printing Decellularized Matrices

Published on: January 7, 2019

7.1K

Related Experiment Videos

Last Updated: Jul 5, 2025

3D Printed Porous Cellulose Nanocomposite Hydrogel Scaffolds
06:36

3D Printed Porous Cellulose Nanocomposite Hydrogel Scaffolds

Published on: April 24, 2019

9.6K
Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold
09:37

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold

Published on: October 23, 2015

12.7K
Novel Process for 3D Printing Decellularized Matrices
08:14

Novel Process for 3D Printing Decellularized Matrices

Published on: January 7, 2019

7.1K

Area of Science:

  • Biomaterials Science
  • Orthopedic Surgery
  • Regenerative Medicine

Background:

  • Large bone defects from trauma present significant reconstructive challenges.
  • Current bone substitutes are often inadequate for substantial bone loss.
  • Developing effective bone regeneration strategies is crucial for patient outcomes and healthcare systems.

Purpose of the Study:

  • To evaluate polycaprolactone (PCL)-based scaffolds enriched with hydroxyapatite (HA), β-tricalcium phosphate (TCP), or Bioglass 45S5 for bone regeneration.
  • To assess the efficacy of these composite scaffolds in a critical-size ovine femoral condyle defect model.
  • To compare the bone regenerative potential of different PCL composite scaffolds.

Main Methods:

  • Development of PCL scaffolds (330 µm channels) enriched with 20% w/w HA, TCP, or Bioglass.
  • Testing scaffolds in a critical-size ovine femoral condyle defect model.
  • Analysis of tissue ingrowth using X-ray computed tomography (XCT), Backscattered Electron Microscopy (BSE), and histomorphometry after 6 weeks.

Main Results:

  • All tested biomaterials successfully promoted new bone formation within the defect.
  • No statistically significant differences in bone formation were observed among the HA, TCP, and Bioglass groups (p > 0.05).
  • PCL-Bioglass scaffolds demonstrated enhanced bone formation in the scaffold's center compared to other materials.

Conclusions:

  • PCL-based scaffolds enriched with HA, TCP, or Bioglass show potential for bone regeneration in critical-sized defects.
  • The PCL-Bioglass composite appears particularly promising for enhancing bone formation in load-bearing sites.
  • These findings support the development of advanced biomaterials for challenging orthopedic reconstructions.