Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bioavailability Enhancement: Drug Solubility Enhancement

Bioavailability Enhancement: Drug Solubility Enhancement

Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...

Bioavailability Enhancement: Drug Permeability Enhancement

Bioavailability Enhancement: Drug Permeability Enhancement

After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Poly(3-hydroxybutyrate)-Based Biomimetic Materials Encapsulated with Amide Derivatives of Chlorin-e6 for Advanced Photodynamic Therapy.

Nanomaterials (Basel, Switzerland)·2026

Same author

An Unusual Component of the Multistep Phosphorelay from Tea Plant (<i>Camellia sinensis</i> L.).

International journal of molecular sciences·2026

Same author

Synthesis and Biological Evaluation of New Quinazolin-4(3H)-One-Coumarin Hybrids Designed as Anticancer and Antibacterial Agents.

International journal of molecular sciences·2026

Same author

Application of Proteins Binding Components of Bacterial Cell Wall for Extraction, Concentration, and Analysis of Biological Samples.

Biochemistry. Biokhimiia·2026

Same author

Alginate Hydrogels: Methods of Preparation and Application in Tissue Engineering and Targeted Drug Delivery.

Biochemistry. Biokhimiia·2026

Same author

Gradient Hydrogels: Fabrication Strategies and Biomedical Applications.

Biochemistry. Biokhimiia·2026

Search research articles

Related Experiment Video

Updated: Jun 27, 2026

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

Thymol-Modified Oleic and Linoleic Acids Encapsulated in Polymeric Nanoparticles: Enhanced Bioactivity, Stability,

Maria B Sokol¹, Vera A Sokhraneva^2,3, Nataliya V Groza²

¹N.M. Emanuel Institute of Biochemical Physics of Russian Academy of Sciences, 119334 Moscow, Russia.

|January 11, 2024

Summary

Modified oleic acid (OA) and linoleic acid (LA) with thymol, creating thymol oleic acid (TOA) and thymol linoleic acid (TLA) derivatives. These were encapsulated in nanoparticles, showing enhanced antimicrobial and anticancer properties for biomedical applications.

Keywords:

PLGA biological activity linoleic acid nanoparticles oleic acid

More Related Videos

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

Author Spotlight: Development and Characterization of Eco-Friendly Lignin-Based Microparticles for Enhanced Delivery of Bioflavonoids

Author Spotlight: Development and Characterization of Eco-Friendly Lignin-Based Microparticles for Enhanced Delivery of Bioflavonoids

Published on: March 1, 2024

Related Experiment Videos

Last Updated: Jun 27, 2026

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

Author Spotlight: Development and Characterization of Eco-Friendly Lignin-Based Microparticles for Enhanced Delivery of Bioflavonoids

Author Spotlight: Development and Characterization of Eco-Friendly Lignin-Based Microparticles for Enhanced Delivery of Bioflavonoids

Published on: March 1, 2024

Area of Science:

Biochemistry
Materials Science
Pharmacology

Background:

Unsaturated fatty acids like oleic acid (OA) and linoleic acid (LA) exhibit antimicrobial and cytostatic properties.
Modifying these fatty acids can enhance their bioavailability, stability, and therapeutic potential.

Purpose of the Study:

To synthesize and characterize thymol derivatives of OA and LA (TOA and TLA).
To encapsulate TOA and TLA into polymeric nanoparticles (TOA-NPs and TLA-NPs).
To evaluate the in vitro biological activity and pharmacokinetic potential of these novel formulations.

Main Methods:

Mathematical simulations (PASS, ADMETlab 2.0) for predicting biological activity and pharmacokinetics.
Chemical synthesis of TOA and TLA via esterification.
Nanoparticle formulation using single-emulsion solvent evaporation.
Characterization using dynamic light scattering, UV-Vis spectroscopy, release studies, and in vitro biological assays.

Main Results:

PASS predicted antimicrobial and anticancer potential for TOA and TLA.
Nanoparticles exhibited sizes of 212-227 nm with high encapsulation efficiency (71-93%).
Formulations demonstrated gradual and prolonged release of TOA and TLA.
TLA-NPs showed superior antibacterial activity against B. cereus and S. aureus, and enhanced cytotoxicity against MCF-7, K562, and A549 cell lines compared to TOA-NPs.

Conclusions:

Novel thymol-fatty acid derivatives and their nanoparticle formulations possess significant antimicrobial and anticancer potential.
The developed nanoparticles offer a promising platform for enhanced delivery and sustained release of active compounds.
These findings support further in vivo investigation of TOA-NPs and TLA-NPs for biomedical applications.