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Related Concept Videos

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Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
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How Do Classical Subtypes Correspond to Endotypes in Atopic Dermatitis?

Tsuyoshi Suzuki1, Shumpei Kondo1, Yasuaki Ogura1

  • 1Department of Dermatology & Skin Oncology, Chutoen General Medical Center, 1-1 Shobugaike, Kakegawa 436-8555, Japan.

International Journal of Molecular Sciences
|January 11, 2024
PubMed
Summary
This summary is machine-generated.

Atopic dermatitis (AD) subtyping is evolving from phenotype to endotype for personalized treatment. Understanding endotypes, especially cytokine-based ones, is key for tailoring therapies to individual patients with AD.

Keywords:
atopic dermatitisendotypeextrinsic typeintrinsic typephenotypesubtype

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Area of Science:

  • Dermatology
  • Immunology
  • Genetics

Background:

  • Atopic dermatitis (AD) is a complex skin condition with diverse patient presentations.
  • Traditional AD classification relies on phenotypic characteristics, which may not fully capture underlying disease mechanisms.
  • The heterogeneity of AD necessitates more precise methods for patient stratification.

Purpose of the Study:

  • To review the concept of atopic dermatitis endotyping.
  • To explore various stratification approaches, including cytokine profiles, barrier function, and biomarkers.
  • To discuss the correlation between classical AD subtypes and emerging endotypes.

Main Methods:

  • Literature review of recent findings on AD mechanisms and endotyping.
  • Analysis of different endotype classification systems (cytokine-based, biomarker-based).
  • Comparison of classical AD subtypes (extrinsic/intrinsic, racial, age-based) with proposed endotypes.

Main Results:

  • Endotyping offers a more accurate patient characterization than phenotyping.
  • Cytokine-based endotypes (Type 2, Type 1, Type 3 high) are particularly useful.
  • Biomarker-based endotyping is emerging for individualized treatment strategies.

Conclusions:

  • AD endotyping is crucial for developing personalized therapeutic choices.
  • Aligning classical subtypes with endotypes will aid clinical understanding and application.
  • Further research is needed to integrate endotyping into daily clinical practice for AD management.