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Dermatofibrosarcoma protuberans--a clinicopathological study of ten cases
The Japanese Journal of Surgery
|November 1, 1986
Summary
Dermatofibrosarcoma protuberans, a skin soft tissue tumor, often recurs due to local invasion. Wide surgical excision is crucial for minimizing recurrence of this low-grade malignancy.
Area of Science:
- Oncology
- Dermatopathology
- Surgical Oncology
Background:
- Dermatofibrosarcoma protuberans (DFSP) is a rare, low-grade soft tissue sarcoma originating in the skin.
- DFSP is characterized by frequent local recurrence and potential for aggressive behavior despite its low-grade classification.
Purpose of the Study:
- To summarize the clinical behavior and histopathological features of dermatofibrosarcoma protuberans.
- To emphasize the importance of surgical management in preventing recurrence of DFSP.
Main Methods:
- Review of clinical and pathological data for DFSP cases.
- Histopathological analysis focusing on mitotic rate, cellularity, and anaplasia.
Main Results:
- DFSP is a locally invasive tumor requiring wide excision to minimize recurrence.
- Low-grade tumors (mitotic rate <5/HPF, low cellularity/anaplasia) exhibit a more indolent clinical course.
- Higher-grade features correlate with more aggressive tumor behavior.
Conclusions:
- Wide surgical excision is the standard treatment for DFSP to achieve local control.
- Histopathological grading provides prognostic information regarding tumor behavior and recurrence risk.