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Updated: Jul 5, 2025
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Evaluation of Drug Sorption to PVC- and Non-PVC-based Tubes in Administration Sets Using a Pump
Published on: March 11, 2017
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Flow Rate Deviation in Infusion Pump: Infusion Set Defect Enables Pump Malfunction and Considerable Accuracy
Axel Hult1,2,3,4,5, Irina Zholobova1,2,3,4,5, Emelie Bäcklin1,2,3,4,5
1Karolinska University Hospital Huddinge, Stockholm, Sweden (Hult, Zholobova, Bäcklin); Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden (Nydert).
Summary
Defective infusion sets can cause volumetric infusion pumps to deliver less medication than programmed, without any alarms. This risk of underinfusion errors threatens patient safety and accurate drug delivery.
Area of Science:
- Medical Devices
- Biomedical Engineering
- Patient Safety
Background:
- Volumetric infusion pumps are critical for medication delivery.
- Flow rate errors (over/underinfusion) are known issues.
- Recent underinfusion errors were reported at a Swedish hospital.
Purpose of the Study:
- Investigate underinfusion errors in volumetric infusion pumps.
- Determine the effect of defective infusion sets on pump accuracy.
- Assess the risk of undetected medication underdelivery.
Main Methods:
- Experimental study using a gravimetric method for flow rate accuracy testing.
- Comparison between manipulated and clinically used defective infusion sets.
- Focus on infusion sets with visible silicone segment elongation.
Main Results:
- Defective infusion sets caused significant accuracy deviations.
- Pumps inaccurately reported higher infused volumes than actual delivery.
- No alarms were triggered for reduced medication output.
- Elongated sets led to substantial underinfusion, not reflected on the pump display.
Conclusions:
- Defective infusion sets pose a serious risk to patient safety.
- Underinfusion errors may go undetected by the pump and clinicians.
- Ensuring infusion set integrity is crucial for accurate medication administration.
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