Related Experiment Video
Updated: Jul 5, 2025
12:08
Improving IV Insulin Administration in a Community Hospital
Published on: June 11, 2012
18.8K
Fingerprinting hyperglycemia using predictive modelling approach based on low-cost routine CBC and CRP diagnostics
Amna Tahir1, Kashif Asghar2, Waqas Shafiq3
1Biomedical Informatics and Engineering Research Laboratory, Department of Life Sciences, Syed Babar Ali School of Science and Engineering, Lahore University of Management Sciences, Lahore, Pakistan.
Scientific Reports
|January 11, 2024
Summary
This study found that combining inflammatory markers with Red Blood Cell (RBC) indices can accurately predict hyperglycemia and borderline hyperglycemia, aiding early diagnosis and intervention.
Area of Science:
- Endocrinology and Metabolism
- Hematology
- Clinical Diagnostics
Background:
- Hyperglycemia, a result of disrupted glucose homeostasis, is exacerbated by lifestyle factors and inflammation, contributing to diabetes mellitus (DM).
- The rising prevalence of type 2 diabetes necessitates early diagnostic and treatment strategies.
- Systemic inflammation and altered Red Blood Cell (RBC) indices are implicated in the pathophysiology of hyperglycemia.
Purpose of the Study:
- To evaluate the discriminatory capacity of inflammatory biomolecules and RBC indices in predicting hyperglycemia and borderline hyperglycemia.
- To develop predictive models for glycemic outcomes using clinical diagnostic data.
- To identify key predictors for different glycemia levels.
Main Methods:
- Retrospective analysis of 208,137 clinical diagnostic entries over five years.
- Inclusion of tests such as Hemoglobin A1c (HbA1c), Complete Blood Count (CBC), Fasting Blood Glucose (FBG), and C-reactive protein (CRP).
- Application of multivariate analysis (MANOVA) and univariate analysis (ANOVA) to identify significant predictors.
Main Results:
- Four glycemic predictive models developed for HbA1c and FBG cohorts, each exceeding 80% predictive accuracy (p < 0.0001).
- Significant discriminatory capacity identified for predictors of different glycemia levels.
- A novel predictor combining inflammatory markers and RBC indices demonstrated high sensitivity and specificity for predicting glycemic outcomes (ROC p < 0.0001).
Conclusions:
- The interplay between inflammation, RBC derangements, and glucose homeostasis can prognosticate hyperglycemic outcomes.
- A sensitive and specific predictor using inflammatory markers and RBC indices can aid in early hyperglycemia detection.
- This predictor can serve as a prophylactic intervention for identifying individuals at risk of hyperglycemia and borderline hyperglycemia.
More Related Videos
07:22Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
Published on: March 7, 2025
230
07:31Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
Published on: May 15, 2020
7.1K
Related Concept Videos
01:15Hypoglycemia and Glucagon
263
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
263
01:15Diabetes: Symptoms, Diagnosis, and Complications
546
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
546
01:22Diabetes Mellitus: Type 2 and Gestational
2.4K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.4K
01:15Diabetes: Management and Pharmacotherapy
285
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
285
01:16Hormones Regulating Blood Glucose
3.4K
Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
In addition to accelerating glucose uptake and utilization, insulin has...
In addition to accelerating glucose uptake and utilization, insulin has...
3.4K
01:25Errors occurring during blood pressure monitoring
730
Blood pressure monitoring is a crucial clinical procedure in diagnosing and managing various cardiovascular conditions. Despite its significance, the accuracy of blood pressure measurements can be compromised by multiple factors, potentially leading to either falsely high or low readings. These inaccuracies are critical as they can significantly impact patient care. So, it is vital to understand these challenges deeply and adopt strategic approaches to minimize errors.
Several factors...
Several factors...
730