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Updated: Jul 5, 2025
08:29
Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA
Published on: February 1, 2019
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Development of polypeptide-based materials toward messenger RNA delivery
Bowen Zhao1, Xiao Zhang1, Molly S Bickle1
1Department of Chemistry, University of Miami, 1301 Memorial Drive, Coral Gables, Florida, 33146, USA. fxz174@miami.edu.
Nanoscale
|January 12, 2024
Summary
Polypeptide-based delivery systems offer a cost-effective and scalable method for messenger RNA (mRNA) therapeutics. This review explores polypeptide synthesis, delivery applications, challenges, and strategies for advancing mRNA carrier development.
Area of Science:
- Biotechnology
- Materials Science
Background:
- Messenger RNA (mRNA) therapeutics show great promise, especially after the COVID-19 pandemic.
- Polypeptide-based mRNA delivery systems are gaining attention due to their favorable characteristics.
Purpose of the Study:
- To review polypeptide synthesis and commonly used polypeptides in mRNA delivery.
- To discuss challenges in mRNA delivery, including extracellular, intracellular, and clinical barriers.
- To highlight strategies for advancing polypeptide-based mRNA delivery systems.
Main Methods:
- Review of scientific literature on polypeptide synthesis.
- Analysis of commonly used polypeptides (classical and cell-penetrating peptides) for mRNA delivery.
- Discussion of existing challenges and proposed strategies for mRNA delivery.
Main Results:
- Polypeptide delivery systems are cost-effective, easily prepared, scalable, biocompatible, and biodegradable.
- Identified key barriers to effective mRNA delivery.
- Outlined various strategies to overcome these barriers in polypeptide-based carriers.
Conclusions:
- Polypeptide-based carriers are a viable and advantageous platform for mRNA delivery.
- Addressing delivery challenges is crucial for the clinical translation of mRNA therapeutics.
- Further development of polypeptide carriers will enhance mRNA therapeutic applications.
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