Related Experiment Video
Updated: Jul 5, 2025
07:34
Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking
Published on: November 17, 2023
690
Association between platelet‑to‑lymphocyte ratio and serum prostate specific antigen
Bowen Hu1, Minbo Yan2, Shuchang Huang2
1Department of Urology, The People's Hospital of Longhua, Shenzhen, Guangdong 518000, P.R. China.
Molecular and Clinical Oncology
|January 12, 2024
Summary
The platelet-to-lymphocyte ratio (PLR) is positively correlated with prostate-specific antigen (PSA) levels in US men. This finding suggests higher PLR may contribute to prostate cancer overdiagnosis.
Area of Science:
- Urology
- Inflammation Research
- Biostatistics
Background:
- Systemic inflammation may affect prostate-specific antigen (PSA) levels.
- The relationship between platelet-to-lymphocyte ratio (PLR) and PSA is not well-established.
Purpose of the Study:
- To investigate the association between PLR and PSA levels.
- To determine if PLR is an independent predictor of PSA concentration.
Main Methods:
- Analysis of data from the National Health and Nutrition Examination Survey (NHANES) database (2001-2010).
- Inclusion of 6,638 adult male participants.
- Statistical analysis controlling for relevant covariates.
Main Results:
- A statistically significant positive correlation was found between PLR and PSA levels.
- Each unit increase in PLR was associated with a 0.004 ng/ml increase in PSA concentration.
- A linear relationship between PLR and PSA was identified in the US male population.
Conclusions:
- PLR is independently and positively associated with PSA levels in US men.
- Elevated PLR may be linked to an increased risk of prostate cancer overdiagnosis.
- Further research is warranted to explore the clinical implications of this association.
