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Combined Facile Synthesis, Purification, and Surface Functionalization Approach Yields Monodispersed Gold Nanorods
Shunping Han1, Khuloud T Al-Jamal1
1Institute of Pharmaceutical Science Faculty of Life Sciences & Medicine King's College London Franklin-Wilkins Building, 150 Stamford Street London SE1 9NH UK.
Particle & Particle Systems Characterization : Measurement and Description of Particle Properties and Behavior in Powders and Other Disperse Systems
|January 12, 2024
Summary
This study optimized gold nanorod (AuNR) synthesis for drug delivery, achieving high purity (>90%) AuNRs. The resulting PEGylated AuNRs demonstrated biocompatibility with cells, making them suitable for therapeutic applications.
Area of Science:
- Nanotechnology
- Biomedical Engineering
- Materials Science
Background:
- Seed-mediated synthesis of gold nanorods (AuNRs) often yields by-products.
- Achieving high purity AuNRs is crucial for applications like drug delivery.
Purpose of the Study:
- To develop a facile method for synthesizing high-purity gold nanorods (AuNRs).
- To optimize AuNRs for drug delivery applications by enhancing biocompatibility and dispersibility.
- To investigate the biocompatibility of synthesized AuNRs with relevant cell lines.
Main Methods:
- Optimized seed-mediated synthesis of AuNRs using cetyltrimethylammonium bromide (CTAB).
- Employed a two-step purification process (dialysis and centrifugation) to achieve high rod purity (>90%).
- Surface functionalization of AuNRs with polyethylene glycol (PEG) to improve biocompatibility.
Main Results:
- Synthesized AuNRs with redshifted longitudinal localized surface plasmon resonance (LLSPR) within the biological transparency window.
- Achieved high purity (>90%) AuNRs, significantly reducing by-product contamination.
- PEGylated AuNRs showed no toxicity to SN4741 and B16F10 cells after 24h incubation.
Conclusions:
- A combined synthesis, purification, and PEGylation strategy yields water-dispersible, monodispersed AuNRs.
- The developed AuNRs are biocompatible and suitable for drug delivery applications.
- This approach offers a promising route for creating advanced nanomaterials for biomedical use.
