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Updated: Jan 31, 2026

Microfluidic Fabrication of Polymeric and Biohybrid Fibers with Predesigned Size and Shape
Published on: January 8, 2014
Size tunable fabrication of magnetic alginate microparticles using flow focusing microfluidics
Victor G Rivera-Llabres1, Kara N Gentry2, Matthew Po1
1Department of Chemical Engineering, University of Florida, Gainesville FL32611, USA.
Abstract:
We report the size tunable formulation of magnetic alginate microparticles (MAMs) using a 3D flow-focusing microfluidic device. The droplet phase consisted of iron oxide nanoparticles (IONPs) in an alginate solution and the continuous phase consisted of fluorocarbon oils. We studied the stability of IONP colloids in alginate and calcium ethylenediamine tetraacetic acid solutions using optical microscopy, dynamic light scattering, and zeta potential measurements. These studies suggest that IONPs coated with polyethylene glycol (PEG) were most stable. We then formulated MAMs using the PEG-coated IONP colloid and studied how MAM average size and coefficient of variance varied as a function of droplet and continuous phase flow rates and viscosities. Droplet and MAM size decreased when the carrier flow rate or viscosity increased, and droplet and MAM size increased when droplet flow rate or viscosity increased. Crosslinking and drying of droplets resulted in MAMs whose diameter was approximately 44% less than the original droplets while maintaining a population coefficient of variance below 8%. Conditions were identified that enable fabrication of MAMs with diameters between 30 - 60 μm with coefficients of variance of ~6-7%. These results may guide future work exploring the role of MAM size on various applications.
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