Reviewing the process intensification landscape through the introduction of a novel, multitiered classification for...

Area of Science:

• Biopharmaceutical Manufacturing
• Process Engineering
• Biotechnology

Background:

• Increasing demand for biopharmaceuticals drives the need for process intensification.
• Current adoption of process intensification is hindered by complexity, cost, and unclear terminology.
• Existing literature lacks a standardized approach, causing confusion in the field.

Purpose of the Study:

• To address the challenges in adopting process intensification in biomanufacturing.
• To propose a defined, leveled approach for implementing downstream process intensification.
• To introduce standardized nomenclature for clarity and consistent application.

Main Methods:

• Comprehensive review of state-of-the-art systems and consumables.
• Analysis of current process intensification case studies in biomanufacturing.
• Development of a tiered implementation strategy with standardized terminology.

Main Results:

• A clear, standardized nomenclature for process intensification is proposed.
• Process intensification can be implemented incrementally as distinct, independent levels.
• This approach facilitates cost-effective adoption for biomanufacturers of all sizes.

Conclusions:

• The proposed leveled approach simplifies the adoption of process intensification.
• Standardized nomenclature reduces confusion and promotes consistent application.
• This strategy enables scalable and economical implementation of process intensification in biopharmaceutical production.