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Related Concept Videos

CRISPR01:59

CRISPR

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Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
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Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
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The basic reaction of homologous recombination (HR) involves two chromatids that contain DNA sequences sharing a significant stretch of identity. One of these sequences uses a strand from another as a template to synthesize DNA in an enzyme-catalyzed reaction. The final product is a novel amalgamation of the two substrates. To ensure an accurate recombination of sequences, HR is restricted to the S and G2 phases of the cell cycle. At these stages, the DNA has been replicated already and the...
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Related Experiment Video

Updated: Jul 5, 2025

CIRCLE-Seq for Interrogation of Off-Target Gene Editing
08:23

CIRCLE-Seq for Interrogation of Off-Target Gene Editing

Published on: November 1, 2024

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Risk-appropriate regulations for gene-editing technologies.

Graham Brookes1, Stuart J Smyth2

  • 1PG Economics Ltd, Dorchester, UK.

GM Crops & Food
|January 12, 2024
PubMed
Summary
This summary is machine-generated.

Gene editing (GE) technologies offer potential solutions for global challenges like food security and biodiversity loss. This study examines GE

Keywords:
GMOsGene editingGlobal Biodiversity FrameworkRegulationSustainable Development Goalsevidence basedrisk appropriate

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Area of Science:

  • Agricultural Science
  • Biotechnology
  • Environmental Science

Background:

  • Global challenges include food security, climate change, and biodiversity depletion.
  • The Global Biodiversity Framework (GBF) sets targets for conservation and sustainable use.
  • Emerging gene editing (GE) technologies present new opportunities in agriculture.

Purpose of the Study:

  • To explore the potential of gene editing (GE) technologies in addressing global challenges.
  • To examine the role of GE in agricultural production aligned with GBF targets.
  • To assess the optimal regulatory environment for GE adoption in agriculture.

Main Methods:

  • Review of scientific literature on gene editing applications in agriculture.
  • Analysis of evidence supporting GE for food security, climate change, and biodiversity.
  • Examination of regulatory frameworks for agricultural innovations, including genetically modified organisms (GMOs).

Main Results:

  • Gene editing technologies show promise for enhancing agricultural sustainability.
  • GE can contribute to meeting specific targets within the Global Biodiversity Framework.
  • A risk-appropriate regulatory environment is crucial for successful GE adoption.

Conclusions:

  • Gene editing offers a significant tool for tackling pressing global environmental and food security issues.
  • Careful consideration of regulatory approaches, informed by GMO experiences, is essential.
  • Facilitating GE adoption can support sustainable agriculture and biodiversity goals.