Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Coagulation problems in human pregnancy.

C W Redman

    Postgraduate Medical Journal
    |May 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Pregnancy-related coagulation issues stem from an overactive clotting system, increasing thrombo-embolism risk. A new Factor VIII test aids early diagnosis of pre-eclampsia by detecting clotting system activation.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    HLA-DR is aberrantly expressed at feto-maternal interface in pre-eclampsia.

    Journal of reproductive immunology·2018
    Same author

    Angiogenic factors: potential to change clinical practice in pre-eclampsia?

    BJOG : an international journal of obstetrics and gynaecology·2017
    Same author

    Trophoblast Glycoprotein (TPGB/5T4) in Human Placenta: Expression, Regulation, and Presence in Extracellular Microvesicles and Exosomes.

    Reproductive sciences (Thousand Oaks, Calif.)·2017
    Same author

    Pre-eclampsia: Definitions, paternal contributions and a four stage model.

    Pregnancy hypertension·2015
    Same author

    Isolation of syncytiotrophoblast microvesicles and exosomes and their characterisation by multicolour flow cytometry and fluorescence Nanoparticle Tracking Analysis.

    Methods (San Diego, Calif.)·2015
    Same author

    Placental miR-1301 is dysregulated in early-onset preeclampsia and inversely correlated with maternal circulating leptin.

    Placenta·2014
    Same journal

    Diastolic dysfunction and diabetes: the DIADAD study-a retrospective cohort study from Liverpool.

    Postgraduate medical journal·2026
    Same journal

    Diagnostic reasoning in clinical neurology: a comprehensive primer.

    Postgraduate medical journal·2026
    Same journal

    Asthma therapy over 100 years.

    Postgraduate medical journal·2026
    Same journal

    Transformation of trauma and orthopaedics across the six industrial revolutions: from mechanization to artificial intelligence applications in enhancing patient care.

    Postgraduate medical journal·2026
    Same journal

    Increased food prices and changes in food consumption behavior: an early precursor to malnutrition, and widespread food insecurity among the Egyptian population.

    Postgraduate medical journal·2026
    Same journal

    Acute kidney injury in rhabdomyolysis defined by serum creatine kinase ≥1000 IU/L: association with creatine kinase levels.

    Postgraduate medical journal·2026
    See all related articles

    Area of Science:

    • Obstetrics
    • Hematology
    • Reproductive Medicine

    Background:

    • Pregnancy naturally involves changes in the coagulation system, increasing the risk of thrombo-embolism.
    • Placental pathology is often linked to obstetric complications causing coagulation problems, such as abruptio placentae and pre-eclampsia.
    • Abnormal clotting system activation is an early sign in pre-eclampsia, but its primary role is debated.

    Purpose of the Study:

    • To investigate the role of coagulation system overactivity in pregnancy-related thrombo-embolism.
    • To explore the utility of a novel Factor VIII consumption test in diagnosing early pre-eclampsia.
    • To evaluate the potential of anticoagulant therapy in managing pre-eclampsia.

    Main Methods:

    • Review of coagulation system overactivity during pregnancy.

    Related Experiment Videos

  • Introduction of a new test to estimate Factor VIII consumption.
  • Analysis of Factor VIII consumption as an index for clotting system activation.

    • Main Results:

    • The intrinsic clotting system's overactivity is a primary cause of coagulation problems and thrombo-embolism in pregnancy.
    • Placental pathology is a common factor in obstetric complications leading to clotting issues.
    • A new Factor VIII consumption test is a sensitive indicator of early clotting system activation, useful for diagnosing early pre-eclampsia.

    Conclusions:

    • Coagulation problems in pregnancy are linked to intrinsic clotting system overactivity.
    • The role of anticoagulant treatment in pre-eclampsia management remains uncertain.
    • Factor VIII consumption testing shows promise for early pre-eclampsia diagnosis.