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Microstructural white matter abnormalities in overactive bladder syndrome evaluation with diffusion kurtosis imaging

Long Zuo1, Tian Tian1, Biao Wang2

  • 1Department of Radiology, Beijing Chao-Yang Hospital, Capital Medical University, 8 Gongren Tiyuchang Nanlu, Chaoyang District, Beijing, 100020, China.

World Journal of Urology
|January 13, 2024
PubMed
Summary

Diffusion kurtosis imaging reveals white matter changes in overactive bladder syndrome (OAB). Altered microstructural parameters like kurtosis fractional anisotropy (KFA) may serve as diagnostic biomarkers for OAB.

Keywords:
DKI-derived parametersDiffusion kurtosis imagingOveractive bladder syndromeTract-based spatial statistics

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Area of Science:

  • Neuroimaging
  • Urology
  • Radiology

Background:

  • Overactive bladder syndrome (OAB) is a condition affecting bladder function.
  • The underlying white matter (WM) microstructural changes in OAB are not fully understood.

Purpose of the Study:

  • To investigate WM microstructural alterations in OAB patients using diffusion kurtosis imaging (DKI).
  • To explore the diagnostic potential of DKI-derived parameters in OAB.

Main Methods:

  • Prospective study comparing 30 OAB patients with 30 healthy controls (HC).
  • Tract-based spatial statistics (TBSS) applied to DKI data to assess WM parameters (KFA, FA, MK, MD).
  • Correlation analysis between DKI parameters and OAB Symptom Score (OABSS); ROC curve analysis for diagnostic performance.

Main Results:

  • OAB patients showed significantly decreased KFA and FA compared to HC.
  • OAB patients exhibited significantly increased MK and MD compared to HC.
  • KFA in the genu of corpus callosum and FA in the anterior corona radiata correlated with OABSS scores. KFA demonstrated superior diagnostic performance.

Conclusions:

  • DKI is a valuable tool for investigating OAB pathophysiology.
  • DKI-derived parameters show potential as biomarkers for OAB clinical diagnosis.