Related Experiment Video
Updated: Jul 5, 2025

Author Spotlight: Advancements and Challenges in β-Cells Differentiation from Pluripotent Stem Cells
Published on: February 2, 2024
Generation of a human induced pluripotent stem cell line overexpressing CCL22 with islet cells differentiation
Duan Jinliang1, Bai Fang1, Zhu Xiaofeng1
1Organ Transplantation Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong,China; Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial International Cooperation Base of Science and Technology(Organ Transplantation), Guangzhou, Guangdong, China.
Abstract:
CCL22 is a macrophage-derived immunosuppressive chemokine that recruits regulatory T cells through the CCL22:CCR4 axis, playing an important role in homeostatic and inflammatory responses. A CCL22-overexpressing human induced pluripotent stem cell line (CNNDi001-A-2) was generated by lentiviral transduction to further study the function of CCL22. The cell line was confirmed to have normal proliferation and pluripotency and could be further differentiated into islet cells for cell replacement therapy in diabetes.
Related Concept Videos
iPS Cell Differentiation
Induced Pluripotent Stem Cells
Somatic...

