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Aberrant interhemispheric structural and functional connectivity within whole brain in schizophrenia.
Pan Wang1, Yuan Jiang1, Bharat B Biswal2
1The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Schizophrenia patients show altered white matter connectivity, impacting visual and auditory information transfer. These changes correlate with symptom severity and cognitive function, offering new insights into the disorder.
Area of Science:
- Neuroscience
- Psychiatry
- Medical Imaging
Background:
- Schizophrenia's etiology is unclear, with prior research focusing on gray matter.
- White matter functional connectivity in schizophrenia remains understudied.
Purpose of the Study:
- To investigate interhemispheric functional and structural white matter connectivity in schizophrenia.
- To explore the relationship between white matter alterations and clinical/cognitive measures.
Main Methods:
- Utilized fMRI data from 45 schizophrenia patients and 75 healthy controls.
- Employed voxel-mirrored homotopic connectivity (VMHC) and fiber tracking.
- Analyzed connectivity in bilateral regions including the corpus callosum.
Main Results:
- Schizophrenia patients exhibited reduced VMHC in key brain regions and the corpus callosum.
- Fiber tracking revealed altered structural connectivity in relevant white matter tracts.
- Connectivity changes correlated with symptom severity (SAPS scores) and cognitive function (Matrix Reasoning).
Conclusions:
- Findings highlight the role of white matter dysfunction in schizophrenia.
- Novel perspective on abnormal interhemispheric information transfer in schizophrenia.
- Suggests white matter functional imaging as a valuable tool for schizophrenia research.
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